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製品番号: HY-W237439

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SEN205A

SEN205A is a fragment compound that binds to the hydrophobic pocket of human S100B (K_d=0.5-1.0 mM), which is the key region for the interaction of S100B with TRTK-12 and p53, and SEN205A can be displaced from this site by TRTK-12. SEN205A exhibits excellent in vitro ADME properties, including high metabolic stability, chemical stability, and good solubility under physiological pH conditions. SEN205A can serve as a starting fragment for structure-based optimization to develop inhibitors targeting the S100B-p53 protein-protein interaction and investigate the pathogenesis of malignant melanoma.

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CAS 番号: 958712-85-1
分子式: C₁₃H₁₄ClN₃O
分子量:263.73

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

SEN205A 構造式

CAS 番号: 958712-85-1

価格（税別）

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

SEN205A (800 μM; 5-fold molar excess over monomeric S100B; 0.5-1 equivalents TRTK-12) binds to the p53/TRTK-12 interaction site of human S100B with an estimated K_d of 0.5-1.0 mM, and is fully displaceable from the site by the high-affinity TRTK-12 peptide^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 958712-85-1
分子量 263.73
分子式 C₁₃H₁₄ClN₃O
SMILES

ClC=1C=CC(=CC1)C2=NOC(=N2)C3CNCCC3
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Agamennone M, et al. Fragmenting the S100B-p53 interaction: combined virtual/biophysical screening approaches to identify ligands. ChemMedChem. 2010;5(3):428-435. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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