SFI003
Based on 1 Customer Validation
SFI003 is a SRSF3 inhibitor that drives CRC cell apoptosis via the SRSF3/DHCR24/ROS axis and exhibits potent antitumor effects both in vitro and in vivo.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.75%
- CAS 番号: 2361332-90-1
- 分子式: C19H17N5OS
- 分子量:363.44
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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Apoptosis Compound Library
HY-L003
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Immunology/Inflammation Compound Library
HY-L007
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Metabolism/Protease Compound Library
HY-L012
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NF-κB Signaling Compound Library
HY-L014
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Anti-Cancer Compound Library
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Anti-Aging Compound Library
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Cysteine Targeted Covalent Library
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Cell Death Library
HY-L162
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library
HY-L199
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High-Throughput Bioactive Compound Library
HY-L205
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Lactylation Compound Library
HY-L249
生物活性
SFI003 (0-50 μM, 0-72 h) inhibits the proliferation of HCT116 and SW480 cells in a dose- and time-dependent manner with IC50values of 8.78 µM and 48.67 µM, respectively[1].
SFI003 (0-50 μM, 24-72 h) induces apoptosis in HCT-116 and SW480 cells[1].
SFI003 (0-50 μM, 24-72 h) induces ROS generation in both HCT-116 and SW480 cells in a dose-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HCT-116 and SW480 cells
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Concentration:10, 20, 50 μM
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Incubation Time:24, 48, 72 h
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Result:Inhibited the activity of Akt (p-Akt) and mTOR (p-mTOR).
Inhibited DHCR24 protein expression.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Subcutaneous injection of HCT-116 and SW480 cells into aplastic male SCID mice[1]
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Dosage:100 and 200 mg/kg
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Administration:Oral gavage (p.o.) for two weeks
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Result:At a dose of 200 mg/kg, the tumors in half of the mice disappeared, and at a dose of 100 mg/kg, the tumors in some mice also disappeared.
化学情報
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CAS 番号 2361332-90-1
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性状 Solid
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分子量 363.44
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分子式 C19H17N5OS
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Color Yellow to brown
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SMILES
COC(C=C1)=CC=C1C2=CSC(N/N=C(C3=NC4=CC=CC=C4N3)\C)=N2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 125 mg/mL (343.94 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (272 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.7515 mL | 13.7574 mL | 27.5149 mL | 68.7871 mL |
| 5 mM | 0.5503 mL | 2.7515 mL | 5.5030 mL | 13.7574 mL | |
| 10 mM | 0.2751 mL | 1.3757 mL | 2.7515 mL | 6.8787 mL | |
| 15 mM | 0.1834 mL | 0.9172 mL | 1.8343 mL | 4.5858 mL | |
| 20 mM | 0.1376 mL | 0.6879 mL | 1.3757 mL | 3.4394 mL | |
| 25 mM | 0.1101 mL | 0.5503 mL | 1.1006 mL | 2.7515 mL | |
| 30 mM | 0.0917 mL | 0.4586 mL | 0.9172 mL | 2.2929 mL | |
| 40 mM | 0.0688 mL | 0.3439 mL | 0.6879 mL | 1.7197 mL | |
| 50 mM | 0.0550 mL | 0.2751 mL | 0.5503 mL | 1.3757 mL | |
| 60 mM | 0.0459 mL | 0.2293 mL | 0.4586 mL | 1.1465 mL | |
| 80 mM | 0.0344 mL | 0.1720 mL | 0.3439 mL | 0.8598 mL | |
| 100 mM | 0.0275 mL | 0.1376 mL | 0.2751 mL | 0.6879 mL |
SFI003 関連分類
HY-148660 関連分類
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