Sinococuline
Based on 1 Customer Validation
Sinococuline is a potent anti-dengue agent that is effective against all four serotypes of dengue virus (DENV). Sinococuline is also an effective tumor cell growth inhibitor.
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- 純度: 98.29%
- CAS 番号: 109351-36-2
- 分子式: C18H23NO5
- 分子量:333.38
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
37 μM
Compound: 9
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Displacement of [3H]deltorphin-2 from human delta opioid receptor expressed in HEK293 cell membrane
Displacement of [3H]deltorphin-2 from human delta opioid receptor expressed in HEK293 cell membrane
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[PMID: 20426456] |
| Hepatocyte | IC50 |
4.5 μM
Compound: 2
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Antimalarial activity against Plasmodium yoelii 265 sporozoites in primary mice (Mus musculus) hepatocytes after 48 hrs
Antimalarial activity against Plasmodium yoelii 265 sporozoites in primary mice (Mus musculus) hepatocytes after 48 hrs
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[PMID: 18456502] |
Sinococuline (0.5-5.0 μg/mL; 6 days) inhibits the non-structural protein-1 (NS1) release by DENV-2 infected Vero cells[1].
Sinococuline (0-40 μg/mL; 48 h) inhibits pan-DENV infection in Vero cells, with IC50s of 0.2, 0.08, 0.17, and 0.1 μg/mL for DENV-1, DENV-2, DENV-3, and DENV-4, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:AG129 mouse (an interferon type I and II receptor-deficient mice) with severe DENV-infection[1]
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Dosage:0.5, 1.0, 2.0 mg/kg/day
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Administration:I.p. twice a day for 5 days
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Result:Showed delayed mortality and survived significantly of mice, but none of the mice could survive till the end of experiment at the dose of 0.5 mg/kg/day.
The mice completely survived through the entire course of experiment at the dose of 2.0 mg/kg/day.
化学情報
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CAS 番号 109351-36-2
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性状 Solid
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分子量 333.38
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分子式 C18H23NO5
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Color White to off-white
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SMILES
COC1=C([C@]([H])(C2)NCC3)[C@]3(C4=C2C=CC(OC)=C4O)C[C@H](O)[C@@H]1O
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
純度とドキュメンテーション
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データシート (277 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Sinococuline 関連分類
HY-N11096 関連分類
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