Sotolone
Based on 1 Customer Validation
Sotolone (Dimethylhydroxyfuranone) is an activator of the human olfactory receptor OR8D1. Sotolone activates the human olfactory receptor OR8D1, with EC50 values of 84.98 μM and 167.2 μM for its S-enantiomer and R-enantiomer, respectively. Sotolone has unique aroma profiles: (R)-sotolone exhibits smoky, burnt, herbal and grassy notes; (S)-sotolone presents sweet, milky, sour and nutty notes. Sotolone also acts as an antifungal agent, showing moderate inhibitory activity against Magnaporthe oryzae in vitro.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 95.0%
- CAS 番号: 28664-35-9
- 分子式: C6H8O3
- 分子量:128.13
-
保管条件:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
-
溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
-
HY-N7078
Spiculisporic acidBiosurfactant -
HY-N7078R
Spiculisporic acid (Standard)Biosurfactant -
HY-N8829
(-)-MyrtenolMyrtenol Enantiomer -
HY-W791537
Linalyl formateDrug Derivative -
HY-W003972
2,6-DimethoxyphenolLaccase Substrate -
HY-126070
N-Butyl cinnamateBiochemical Reagent -
HY-W142457
DihydromyrcenolFlavor Ingredient -
HY-W003972R
2,6-Dimethoxyphenol (Standard)Standard of 2,6-Dimethoxyphenol -
HY-W744618
AmbrettolideMacrolide-type Musk -
HY-N8829R
(-)-Myrtenol (Standard)Myrtenol Enantiomer -
HY-W012779
5-Methylhept-2-en-4-oneBiochemical Assay Reagent
生物活性
製品説明
体外実験
Sotolone (200 µg/mL; 2-6 days) exhibits weak to moderate in vitro inhibitory activity against Magnaporthe oryzae BV, Sclerotium rolfsii, and Phytophthora capsici, with IC50 values of 256.0 µg/mL, 333.7 µg/mL, and 279.2 µg/mL respectively, and weaker activity against other tested phytopathogenic fungi[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
-
CAS 番号 28664-35-9
-
性状 Liquid (Density: 1.049 g/cm3)
-
分子量 128.13
-
分子式 C6H8O3
-
Color Colorless to light yellow
-
SMILES
O=C1OC(C(=C1O)C)C
-
別名
Dimethylhydroxyfuranone
-
Structure Classification
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
体外:
DMSO : 100 mg/mL (780.46 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
体内:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 5 mg/mL (39.02 mM); Clear solution
This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 5 mg/mL (39.02 mM); Clear solution
This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
-
-
-
-
Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
-
%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
-
%+
-
+%Tween-80 + +
-
%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
純度とドキュメンテーション
-
データシート (277 KB)
-
SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
-
取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 7.8046 mL | 39.0229 mL | 78.0457 mL | 195.1143 mL |
| 5 mM | 1.5609 mL | 7.8046 mL | 15.6091 mL | 39.0229 mL | |
| 10 mM | 0.7805 mL | 3.9023 mL | 7.8046 mL | 19.5114 mL | |
| 15 mM | 0.5203 mL | 2.6015 mL | 5.2030 mL | 13.0076 mL | |
| 20 mM | 0.3902 mL | 1.9511 mL | 3.9023 mL | 9.7557 mL | |
| 25 mM | 0.3122 mL | 1.5609 mL | 3.1218 mL | 7.8046 mL | |
| 30 mM | 0.2602 mL | 1.3008 mL | 2.6015 mL | 6.5038 mL | |
| 40 mM | 0.1951 mL | 0.9756 mL | 1.9511 mL | 4.8779 mL | |
| 50 mM | 0.1561 mL | 0.7805 mL | 1.5609 mL | 3.9023 mL | |
| 60 mM | 0.1301 mL | 0.6504 mL | 1.3008 mL | 3.2519 mL | |
| 80 mM | 0.0976 mL | 0.4878 mL | 0.9756 mL | 2.4389 mL | |
| 100 mM | 0.0780 mL | 0.3902 mL | 0.7805 mL | 1.9511 mL |
Sotolone 関連分類
HY-W021008 関連分類
Powered by Bioz