Spiclomazine
Based on 1 Customer Validation
Spiclomazine (Clospirazine) is a potent mutant KRAS(G12C) inhibitor that selectively inhibits mutant KRAS-driven pancreatic cancer. Spiclomazine can eliminate KRas-GTP levels in KRAS-driven pancreatic cancer and effectively inhibit RAS-mediated signaling. Spiclomazine significantly inhibits tumor progression in mouse renal capsule xenotransplantation models.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.56%
- CAS 番号: 24527-27-3
- 分子式: C22H24ClN3OS2
- 分子量:446.03
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
[1]|
KRAS(G12C) |
化学情報
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CAS 番号 24527-27-3
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性状 Solid
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分子量 446.03
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分子式 C22H24ClN3OS2
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Color White to off-white
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SMILES
O=C1CSC2(CCN(CCCN3C4=C(C=CC=C4)SC5=CC=C(Cl)C=C35)CC2)N1
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別名
Clospirazine
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
体外:
DMSO : 125 mg/mL (280.25 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (274 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2420 mL | 11.2100 mL | 22.4200 mL | 56.0500 mL |
| 5 mM | 0.4484 mL | 2.2420 mL | 4.4840 mL | 11.2100 mL | |
| 10 mM | 0.2242 mL | 1.1210 mL | 2.2420 mL | 5.6050 mL | |
| 15 mM | 0.1495 mL | 0.7473 mL | 1.4947 mL | 3.7367 mL | |
| 20 mM | 0.1121 mL | 0.5605 mL | 1.1210 mL | 2.8025 mL | |
| 25 mM | 0.0897 mL | 0.4484 mL | 0.8968 mL | 2.2420 mL | |
| 30 mM | 0.0747 mL | 0.3737 mL | 0.7473 mL | 1.8683 mL | |
| 40 mM | 0.0561 mL | 0.2803 mL | 0.5605 mL | 1.4013 mL | |
| 50 mM | 0.0448 mL | 0.2242 mL | 0.4484 mL | 1.1210 mL | |
| 60 mM | 0.0374 mL | 0.1868 mL | 0.3737 mL | 0.9342 mL | |
| 80 mM | 0.0280 mL | 0.1401 mL | 0.2803 mL | 0.7006 mL | |
| 100 mM | 0.0224 mL | 0.1121 mL | 0.2242 mL | 0.5605 mL |
Spiclomazine 関連分類
HY-154313 関連分類
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