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製品番号: HY-117918

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ST-1892

ST-1892 (compound 14) is a highly potent FXR agonist (EC₅₀=7.2 nM) that can be used to study diseases or disorders caused by metabolic inflammation.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 1409411-32-0
分子式: C₁₆H₁₂N₂O₃
分子量:280.28

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

ST-1892 構造式

CAS 番号: 1409411-32-0

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

ST-1892 (compound 14) is a highly potent FXR agonist (EC₅₀=7.2 nM) that can be used to study diseases or disorders caused by metabolic inflammation^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	EC₅₀	0.0072 μM Compound: 14	Agonist activity at human full length FXR expressed in HeLa cells cotransfected with pSG5-human RXR after 24 hrs by Dual-Glo luciferase reporter gene assay Agonist activity at human full length FXR expressed in HeLa cells cotransfected with pSG5-human RXR after 24 hrs by Dual-Glo luciferase reporter gene assay	[PMID: 25934227]

化学情報

CAS 番号 1409411-32-0
分子量 280.28
分子式 C₁₆H₁₂N₂O₃
SMILES

O=C(C1=CC=CC(C2=NC(C3=CC=CC=C3C)=NO2)=C1)O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (268 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Flesch D, et al. Fragmentation of GW4064 led to a highly potent partial farnesoid X receptor agonist with improved drug-like properties[J]. Bioorganic & medicinal chemistry, 2015, 23(13): 3490-3498. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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濃度濃度

体積体積

分子量分子量

希釈計算機

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濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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