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STAT3-IN-27

STAT3-IN-27 (Compound 41) is an orally active inhibitor for phosphorylation of STAT3 (KD is 4.4 μM) and STAT3 transcription (IC50 is 22.57 nM). STAT3-IN-27 inhibits proliferation of various cancer cells with IC50 of 10-500 nM. STAT3-IN-27 arrests the cell cycle at G2/M phase, induces mitochondrial dysfunction and apoptosis in HCT116, inhibits cell migration of HCT116. STAT3-IN-27 exhibits antitumor efficacy in mouse model.

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  • 分子式: C18H21N3O4S
  • 分子量:375.44
  • 保管条件:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • STAT3-IN-27 Chemical Structure
    STAT3-IN-27 構造式
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  • STAT3-IN-27 Chemical Structure
    STAT3-IN-27 Chemical Structure
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  • STAT3-IN-27