Susalimod
Susalimod is an immunomodulating agent and Sulfasalazine (HY-14655) analogue. Susalimod decreases LPS-induced TNF-alpha mouse serum levels.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 149556-49-0
- 分子式: C21H16N2O5S
- 分子量:408.43
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| U-87MG ATCC | IC50 |
70 μM
Compound: 16
|
Inhibition of xc-cystine-glutamate antiporter-mediated cystine uptake in human U87 cells using L-[14C]cystine as substrate after 15 mins by liquid scintillation counting
Inhibition of xc-cystine-glutamate antiporter-mediated cystine uptake in human U87 cells using L-[14C]cystine as substrate after 15 mins by liquid scintillation counting
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[PMID: 21889337] |
化学情報
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CAS 番号 149556-49-0
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分子量 408.43
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分子式 C21H16N2O5S
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SMILES
O=C(O)C1=CC(C#CC2=CC=C(S(=O)(NC3=NC=CC=C3C)=O)C=C2)=CC=C1O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Gozzi P, et al. Pharmacokinetic-pharmacodynamic modeling of the immunomodulating agent susalimod and experimentally induced tumor necrosis factor-alpha levels in the mouse. J Pharmacol Exp Ther. 1999 Oct;291(1):199-203. [Content Brief]
[2]. Påhlman , et al. Extensive biliary excretion of the sulfasalazine analogue, susalimod, but different concentrations in the bile duct in various animal species correlating to species-specific hepatobiliary toxicity. Pharmacol Toxicol. 1999 Sep;85(3):123-9. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Susalimod 関連分類
HY-100485 関連分類
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