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United States

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製品番号: HY-W721611

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Terbucarb

Terbucarb is a phenylcarbamate herbicide. Terbucarb disrupts the mitotic microtubule organizing centers in plant cells, leading to the formation of multipolar spindles and branched phragmoplasts, thereby inhibiting plant growth. An "anaphase star" pattern induced by Terbucarb is observed in onion root tips. Terbucarb is cytotoxic to isolated rat hepatocytes, inducing cell death accompanied by depletion of intracellular ATP, protein thiols and glutathione.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
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CAS 番号: 1918-11-2
分子式: C₁₇H₂₇NO₂
分子量:277.41

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Terbucarb 構造式

CAS 番号: 1918-11-2

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

Terbucarb (27.7-277 μg/mL; 48 h) significantly induces the formation of micronuclei and multinucleated cells in hamster lung cells in a dose-dependent manner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

Terbucarb (1000 mg/kg; p.o.; single dose) does not significantly increase micronucleated reticulocyte frequencies in peripheral blood of male CD-1 mice at 24, 48, or 72 hours post-treatment^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

CD-1 (male, 8 weeks old, 30 g)^[1]
Dosage:

1000 mg/kg
Administration:

p.o.; single dose
Result:

Showed a mean frequency of micronucleated reticulocytes of 1.3 per 1000 reticulocytes at 24 hours post-treatment.
Showed a mean frequency of micronucleated reticulocytes of 3.0 per 1000 reticulocytes at 48 hours post-treatment.
Showed a mean frequency of micronucleated reticulocytes of 1.3 per 1000 reticulocytes at 72 hours post-treatment.
Demonstrated no statistically significant increase in micronucleated reticulocyte frequencies relative to the concurrent corn oil control group at all time points.

化学情報

CAS 番号 1918-11-2
分子量 277.41
分子式 C₁₇H₂₇NO₂
SMILES

O=C(OC=1C(=CC(=CC1C(C)(C)C)C)C(C)(C)C)NC
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Suzuki T, et al. Micronucleus test of herbicide terbutol and its metabolites in cultured Chinese hamster lung cells and male CD-1 mice. Bull Environ Contam Toxicol. 2000 Jan;64(1):66-73.
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