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製品番号: HY-168347

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TH152

TH152 is a reversible, pan ligand for LC3/GABARAP with a K_D of 2 µM. LC3/GABARAP is an autophagy associated protein.

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CAS 番号: 1622917-95-6
分子式: C₂₂H₂₃ClN₄O₄S₂
分子量:507.03

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

TH152 構造式

CAS 番号: 1622917-95-6

容量

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

TH152 is a reversible, pan ligand for LC3/GABARAP with a K_D of 2 µM. LC3/GABARAP is an autophagy associated protein^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	>10 μM Compound: 18	Inhibition of mPGES-1 in human A549 cells microsomes assessed as reduction in PGE2 formation by RP-HPLC assay Inhibition of mPGES-1 in human A549 cells microsomes assessed as reduction in PGE2 formation by RP-HPLC assay	[PMID: 25037914]
PMNL	IC₅₀	>10 μM Compound: 18	Inhibition of 5-LOX in human PMNL cells assessed as reduction in 5-LOX product formation pre-incubated for 15 mins by HPLC based cell-free assay Inhibition of 5-LOX in human PMNL cells assessed as reduction in 5-LOX product formation pre-incubated for 15 mins by HPLC based cell-free assay	[PMID: 25037914]
PMNL	IC₅₀	>10 μM Compound: 18	Inhibition of 5-LOX in human PMNL cells assessed as reduction in 5-LOX product formation pre-incubated for 15 mins by HPLC method Inhibition of 5-LOX in human PMNL cells assessed as reduction in 5-LOX product formation pre-incubated for 15 mins by HPLC method	[PMID: 25037914]

化学情報

CAS 番号 1622917-95-6
分子量 507.03
分子式 C₂₂H₂₃ClN₄O₄S₂
SMILES

OC(C1=CC=C(C=C1)C2=CSC(NC3=CC(Cl)=NC(SC(CCCCCC)C(O)=O)=N3)=N2)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (264 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Schwalm MP, et al., Critical assessment of LC3/GABARAP ligands used for degrader development and ligandability of LC3/GABARAP binding pockets. Nat Commun. 2024 Nov 25;15(1):10204. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

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分子量分子量

希釈計算機

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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