TIM-098a
TIM-098a is a selective AAK1 inhibitor with an IC50 of 0.24 µM. TIM-098a has no inhibitory activity against CaMKK isoforms. TIM-098a inhibits AAK1-regulated endocytosis by suppressing AAK1 kinase activity.
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- 分子式: C18H11N3O2
- 分子量:301.30
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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AAK1 0.24 μM (IC50) |
GAK 1.04 μM (IC50) |
BIKE 5.99 μM (IC50) |
STK16 7.15 μM (IC50) |
TIM-098a can inhibit AAK1 activity in transfected cultured cells (IC50=0.87 µM)[1].
TIM-098a (0.26, 0.82, 2.6, 26 μM; for 6 h) suppresses AAK1-catalyzed Thr156 phosphorylation of GST-AP2µ2 (145-162) in a concentration-dependent manner in AAK1/GST-AP2µ2 (145-162) expressing COS-7 cells[1].
TIM-098a (10 μM; for 6 h) recovers the number of early endosomes in AAK1-transfected cells to the level of untransfected wild type cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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分子量 301.30
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分子式 C18H11N3O2
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SMILES
O=C(C1=CC=CC2=CC(O)=CC3=C12)N4C3=NC5=CC(N)=CC=C54
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
TIM-098a 関連分類
HY-162388 関連分類
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