TK05
Based on 2 publication(s) in Google Scholar
TK05 is a potent and selective inhibitor of leukotriene C4 synthase (LTC4S) with an IC50 of 95 nM.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 97.05%
- CAS 番号: 1245734-61-5
- 分子式: C31H25ClN2O5
- 分子量:540.99
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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MedChemExpress（MCE）の使用を引用している文献 TK05
More
生物活性
IC50: 95 nM (Leukotriene C4 synthase)[1]
TK05 reduces LTC4 production in a dose-dependent manner with an IC50 value of 318 ± 60 nM in MM6 Cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Zymosan A induced peritonitis mouse model[1]
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Dosage:0.12 mg/kg; 6 mg/kg
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Administration:Given i.p.; only once
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Result:0.12 mg/kg of TK05 significantly reduced LTE4 levels, whereas 6 mg/kg body weight of the compound resulted in almost complete inhibition compared with mice treated with only Zymosan A.
化学情報
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CAS 番号 1245734-61-5
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性状 Solid
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分子量 540.99
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分子式 C31H25ClN2O5
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Color Light yellow to yellow
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SMILES
ClC1=CC=C(N(CC2CC2)C3=CC=C(C(C4=CC(C(O)=O)=C(C(C5=CC=C(OC)C=C5)=O)C=C4)=O)N=C3)C=C1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (2)
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Journal Impact Factor
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Most Recent
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Acta Neuropathol Commun
Microglial repopulation reverses radiation-induced cognitive dysfunction by restoring medial prefrontal cortex activity and modulating leukotriene-C4 synthesis. [Abstract]2025 May 19;13(1):105. PMID: 40390112 -
PLoS Pathog
MCL1 promotes porcine epidemic diarrhea virus replication by modulating arachidonic acid metabolic pathway. [Abstract]2026 Apr 24;22(4):e1014170. PMID: 42030333
溶剤 & 溶解度
DMSO : ≥ 100 mg/mL (184.85 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (272 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.8485 mL | 9.2423 mL | 18.4846 mL | 46.2116 mL |
| 5 mM | 0.3697 mL | 1.8485 mL | 3.6969 mL | 9.2423 mL | |
| 10 mM | 0.1848 mL | 0.9242 mL | 1.8485 mL | 4.6212 mL | |
| 15 mM | 0.1232 mL | 0.6162 mL | 1.2323 mL | 3.0808 mL | |
| 20 mM | 0.0924 mL | 0.4621 mL | 0.9242 mL | 2.3106 mL | |
| 25 mM | 0.0739 mL | 0.3697 mL | 0.7394 mL | 1.8485 mL | |
| 30 mM | 0.0616 mL | 0.3081 mL | 0.6162 mL | 1.5404 mL | |
| 40 mM | 0.0462 mL | 0.2311 mL | 0.4621 mL | 1.1553 mL | |
| 50 mM | 0.0370 mL | 0.1848 mL | 0.3697 mL | 0.9242 mL | |
| 60 mM | 0.0308 mL | 0.1540 mL | 0.3081 mL | 0.7702 mL | |
| 80 mM | 0.0231 mL | 0.1155 mL | 0.2311 mL | 0.5776 mL | |
| 100 mM | 0.0185 mL | 0.0924 mL | 0.1848 mL | 0.4621 mL |
TK05 関連分類
HY-117143 関連分類
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