Tropicamide-d3
Based on 1 Customer Validation
Tropicamide-d3 is the deuterium labeled Tropicamide. Tropicamide (Ro 1-7683) is a selective M4 muscarinic acetylcholine receptor antagonist. Tropicamide produces short acting mydriasis (dilation of the pupil) and cycloplegia when applied as eye drops.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.10%
- CAS 番号: 2673270-13-6
- 分子式: C17H17D3N2O2
- 分子量:287.37
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
体外実験
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
アプリケーション
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
化学情報
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CAS 番号 2673270-13-6
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非標識Cas 1508-75-4
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性状 Solid
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分子量 287.37
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分子式 C17H17D3N2O2
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Color White to off-white
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SMILES
[2H]C([2H])([2H])CN(CC1=CC=NC=C1)C(C(C2=CC=CC=C2)CO)=O
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別名
Ro 1-7683-d3
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
体外:
DMSO : ≥ 30 mg/mL (104.40 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Ethanol : ≥ 30 mg/mL (104.40 mM)
DMF : ≥ 30 mg/mL (104.40 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
[2]. Lazareno, S., N.J. Buckley, and F.F. Roberts, Characterization of muscarinic M4 binding sites in rabbit lung, chicken heart, and NG108-15 cells. Mol Pharmacol, 1990. 38(6): p. 805-15. [Content Brief]
[3]. Hernandez, M., et al., Different muscarinic receptor subtypes mediating the phasic activity and basal tone of pig isolated intravesical ureter. Br J Pharmacol, 1993. 110(4): p. 1413-20. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / Ethanol / DMF | 1 mM | 3.4798 mL | 17.3992 mL | 34.7983 mL | 86.9959 mL |
| 5 mM | 0.6960 mL | 3.4798 mL | 6.9597 mL | 17.3992 mL | |
| 10 mM | 0.3480 mL | 1.7399 mL | 3.4798 mL | 8.6996 mL | |
| 15 mM | 0.2320 mL | 1.1599 mL | 2.3199 mL | 5.7997 mL | |
| 20 mM | 0.1740 mL | 0.8700 mL | 1.7399 mL | 4.3498 mL | |
| 25 mM | 0.1392 mL | 0.6960 mL | 1.3919 mL | 3.4798 mL | |
| 30 mM | 0.1160 mL | 0.5800 mL | 1.1599 mL | 2.8999 mL | |
| 40 mM | 0.0870 mL | 0.4350 mL | 0.8700 mL | 2.1749 mL | |
| 50 mM | 0.0696 mL | 0.3480 mL | 0.6960 mL | 1.7399 mL | |
| 60 mM | 0.0580 mL | 0.2900 mL | 0.5800 mL | 1.4499 mL | |
| 80 mM | 0.0435 mL | 0.2175 mL | 0.4350 mL | 1.0874 mL | |
| 100 mM | 0.0348 mL | 0.1740 mL | 0.3480 mL | 0.8700 mL |
Tropicamide-d3 関連分類
HY-B0321S 関連分類
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