1508-75-4
1508-75-4
Chemical Structure
Tropicamide
Synonym(s): Ro 1-7683
- CAS No.: 1508-75-4
- Formula:C17H20N2O2
- Molecular Weight:284.35
IUPAC Name: N-ethyl-3-hydroxy-2-phenyl-N-(pyridin-4-ylmethyl)propanamide
InChIKey: BGDKAVGWHJFAGW-UHFFFAOYSA-N
SMILES: O=C(N(CC)CC1=CC=NC=C1)C(C2=CC=CC=C2)CO
Biological Activity: Tropicamide (Ro 1-7683) is a selective M4 muscarinic acetylcholine receptor antagonist. When used as an eye drop, Tropicamide causes short-term mydriasis (pupil dilation) and cycloplegia. Tropicamide can be used in the research of neurological diseases, such as epilepsy[1][2][3][4].
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Tropicamide | 98.87% | Tropicamide (Ro 1-7683) is a selective M4 muscarinic acetylcholine receptor antagonist. When used as an eye drop, Tropicamide causes short-term mydriasis (pupil dilation) and cycloplegia. Tropicamide can be used in the research of neurological diseases, such as epilepsy. | ||||||||||||||||||||
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Tropicamide (Standard) | ≥98% | Tropicamide (Standard) is the analytical standard of Tropicamide. This product is intended for research and analytical applications. Tropicamide (Ro 1-7683) is a selective M4 muscarinic acetylcholine receptor antagonist. Tropicamide produces short acting mydriasis (dilation of the pupil) and cycloplegia when applied as eye drops. | ||||||||||||||||||||
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Tropicamide-d3 | 99.10% | Tropicamide-d3 is the deuterium labeled Tropicamide. Tropicamide (Ro 1-7683) is a selective M4 muscarinic acetylcholine receptor antagonist. Tropicamide produces short acting mydriasis (dilation of the pupil) and cycloplegia when applied as eye drops. | ||||||||||||||||||||
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References
- [1]. Lazareno, S., N.J. Buckley, and F.F. Roberts, Characterization of muscarinic M4 binding sites in rabbit lung, chicken heart, and NG108-15 cells. Mol Pharmacol, 1990. 38(6): p. 805-15. [Content Brief]
- [2]. Hernandez, M., et al., Different muscarinic receptor subtypes mediating the phasic activity and basal tone of pig isolated intravesical ureter. Br J Pharmacol, 1993. 110(4): p. 1413-20. [Content Brief]
- [3]. Veeraragavan S, et al. The modulation of fragile X behaviors by the muscarinic M4 antagonist, tropicamide. Behav Neurosci. 2011 Oct;125(5):783-90. [Content Brief]
- [4]. Betz AJ, et al. The muscarinic receptor antagonist tropicamide suppresses tremulous jaw movements in a rodent model of parkinsonian tremor: possible role of M4 receptors. Psychopharmacology (Berl). 2007 Oct;194(3):347-59. [Content Brief]
