1508-75-4
1508-75-4
Chemical Structure
Tropicamide
Synonym(s): Ro 1-7683
- CAS No.: 1508-75-4
- Formula:C17H20N2O2
- Molecular Weight:284.35
IUPAC Name: N-ethyl-3-hydroxy-2-phenyl-N-(pyridin-4-ylmethyl)propanamide
InChIKey: BGDKAVGWHJFAGW-UHFFFAOYSA-N
SMILES: O=C(N(CC)CC1=CC=NC=C1)C(C2=CC=CC=C2)CO
Biological Activity: Tropicamide (Ro 1-7683) is a selective M4 muscarinic acetylcholine receptor antagonist. When used as an eye drop, Tropicamide causes short-term mydriasis (pupil dilation) and cycloplegia. Tropicamide can be used in the research of neurological diseases, such as epilepsy[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Tropicamide | 98.87% | Tropicamide (Ro 1-7683) is a selective M4 muscarinic acetylcholine receptor antagonist. When used as an eye drop, Tropicamide causes short-term mydriasis (pupil dilation) and cycloplegia. Tropicamide can be used in the research of neurological diseases, such as epilepsy. | ||||||||||||||||||||
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Tropicamide (Standard) | ≥98% | Tropicamide (Standard) is the analytical standard of Tropicamide. This product is intended for research and analytical applications. Tropicamide (Ro 1-7683) is a selective M4 muscarinic acetylcholine receptor antagonist. Tropicamide produces short acting mydriasis (dilation of the pupil) and cycloplegia when applied as eye drops. | ||||||||||||||||||||
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Tropicamide-d3 | 99.10% | Tropicamide-d3 is the deuterium labeled Tropicamide. Tropicamide (Ro 1-7683) is a selective M4 muscarinic acetylcholine receptor antagonist. Tropicamide produces short acting mydriasis (dilation of the pupil) and cycloplegia when applied as eye drops. | ||||||||||||||||||||
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HPB | 99.11% | HPB (HDAC6 inhibitor HPB) is a selective HDAC6 inhibitor with an IC50 of 31 nM. HPB exhibits >30-flod selectivity for HDAC6 over HDAC1. | ||||||||||||||||||||
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PRL-8-53 | PRL-8-53 is an orally active, blood-brain barrier-permeable benzoate derivative with potent spasmolytic activity and central nervous system regulatory activity. PRL-8-53 acts on dopamine, serotonin and cholinergic-related targets, enhances dopamine activity, partially inhibits serotonin function and elicits cholinergic responses, thereby maintaining neurotransmitter balance in the central nervous system. PRL-8-53 improves learning ability, short-term memory and long-term memory in animals. PRL-8-53 can be used in central nervous system-related research. | |||||||||||||||||||||
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N-Methyl benzedrone hydrochloride | N-Methyl benzedrone hydrochloride is a drug derivative. | |||||||||||||||||||||
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Nialamide | 96.29% | Nialamide is a non-selective monoamine oxidase (MAO) inhibitor. Nialamide inhibits MAO and regulates ROS production. Nialamide induces hyperkinesis in animals, enhances the anticonvulsant effect of Diphenylhydantoin in mice, increases rectal temperature, and enhances the pressor effect of Norepinephrine. Nialamide can be used in the research of depression, inflammatory diseases, neurodegenerative diseases, and hypertension. | ||||||||||||||||||||
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Nialamide hydrochloride | Nialamide hydrochloride is a non-selective monoamine oxidase (MAO) inhibitor. Nialamide hydrochloride inhibits MAO and regulates ROS production. Nialamide hydrochloride induces hyperkinesis in animals, enhances the anticonvulsant effect of Diphenylhydantoin in mice, increases rectal temperature, and enhances the pressor effect of Norepinephrine. Nialamide hydrochloride can be used in the research of depression, inflammatory diseases, neurodegenerative diseases, and hypertension. | |||||||||||||||||||||
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2-(Benzyl(methyl)amino)-1-(3-hydroxyphenyl)ethanone hydrochloride (Standard) | ≥98% | 2-(Benzyl(methyl)amino)-1-(3-hydroxyphenyl)ethanone hydrochloride (Standard) is the analytical standard of 2-(Benzyl(methyl)amino)-1-(3-hydroxyphenyl)ethanone hydrochloride. This product is intended for research and analytical applications. | ||||||||||||||||||||
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N-(2-(pyridin-4-yl)ethyl)isonicotinamide | N-(2-(pyridin-4-yl)ethyl)isonicotinamide (4-PyridinecarboxaMide, N-[2-(4-pyridinyl)ethyl]- (4-Peia)) is a metal-organic framework (MOF). | |||||||||||||||||||||
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N-Benzyl MC hydrochloride | N-Benzyl MC hydrochloride is a drug derivative. | |||||||||||||||||||||
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N,N-Dibenzylacetamide | N,N-Dibenzylacetamide is a drug impurity. | |||||||||||||||||||||
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References
- [1]. Lazareno, S., N.J. Buckley, and F.F. Roberts, Characterization of muscarinic M4 binding sites in rabbit lung, chicken heart, and NG108-15 cells. Mol Pharmacol, 1990. 38(6): p. 805-15. [Content Brief]
- [2]. Hernandez, M., et al., Different muscarinic receptor subtypes mediating the phasic activity and basal tone of pig isolated intravesical ureter. Br J Pharmacol, 1993. 110(4): p. 1413-20. [Content Brief]
- [3]. Veeraragavan S, et al. The modulation of fragile X behaviors by the muscarinic M4 antagonist, tropicamide. Behav Neurosci. 2011 Oct;125(5):783-90. [Content Brief]
- [4]. Betz AJ, et al. The muscarinic receptor antagonist tropicamide suppresses tremulous jaw movements in a rodent model of parkinsonian tremor: possible role of M4 receptors. Psychopharmacology (Berl). 2007 Oct;194(3):347-59. [Content Brief]
