Tyk2-IN-28
Tyk2-IN-28 is an orally active and selective TYK2 inhibitor with an IC50 of 0.9 nM. Tyk2-IN-28 also inhibits JAK2 kinase activity with an IC50 of 4 nM. Tyk2-IN-28 blocks inflammatory cytokine signaling. Tyk2-IN-28 reduces paw swelling in mouse models. Tyk2-IN-28 can be used for research on psoriasis.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C23H21N9
- 分子量:423.47
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
[1]|
JAK1 10 nM (IC50) |
Tyk2 0.9 nM (IC50) |
JAK2 4 nM (IC50) |
JAK3 189 nM (IC50) |
体外実験
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:IL-23-induced psoriasis[1]
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Dosage:10, 20, 50 mg/kg
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Administration:p.o.; twice daily; 6 h interval; for 8 consecutive day
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Result:Had no significant effect on the body weight of C57BL/6 mice in the model of IL-23-induced abnormal epidermal hyperplasia of the ear.
Inhibited the increase in ear thickness and reduces ear weight.
化学情報
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分子量 423.47
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分子式 C23H21N9
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SMILES
CN1N=CC(C2=CN3N=CC=C3C(C4=CN([C@@]5(CC#N)C[C@]6(C[C@H](C#N)C6)C5)N=C4)=N2)=C1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Tyk2-IN-28 関連分類
HY-187467 関連分類
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