UCB7362
UCB7362 is an orally active and potent antimalarial plasmepsin X (PMX) inhibitor, with an IC50 of 7 nM. UCB7362 inhibits parasite growth.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C25H27Cl2N5O3
- 分子量:516.42
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
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Plasmodium |
UCB7362 is substantially more potent against PMX than PMIX with an IC50 of 7 nM for the former compared to 142 nM for the latter[1].
UCB7362 also demonstrates an improvement in selectivity against Cat D and Renin with an IC50 of 3889 nM and >10,000 nM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
UCB7362 (IV (1 mg/kg), PO (10 mg/kg); once) shows moderate clearance in dog and cynomolgus monkey and moderate-high in rat[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Pf (Plasmodium falciparum) SCID mouse model[1]
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Dosage:10, 25 and 60 mg/kg
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Administration:Oral administration, twice a day, for 4 days, with the second administration 10 h after the first one
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Result:Cleared parasitemia from peripheral blood in a dose-dependent manner.
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Animal Model:Sprague Dawley rat[1]
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Dosage:1 mg/kg, 10 mg/kg
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Administration:IV (1 mg/kg), PO (10 mg/kg); once (Pharmacokinetic Analysis)
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Result:Pharmacokinetic Parameters of UCB7362 in Sprague-Dawley rats[1].
IV (1 mg/kg) PO (10 mg/kg) CL (mL/(min kg)) 43.9 Vss (L/kg) 5.72 Tmax (h) 3 Cmax (nM) 246 AUC0-24 (nM∗h) 793 1410 t1/2 (h) 2.1 F (%) 11
化学情報
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分子量 516.42
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分子式 C25H27Cl2N5O3
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SMILES
O=C(NC1=CC=CC([C@@](CC(N2[C@@H]3C[C@H](C)OCC3)=O)(C)NC2=N)=C1Cl)C4=CC=CC(C#N)=C4.[H]Cl
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
UCB7362 関連分類
HY-151568 関連分類
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