UDA-6
UDA-6 is a potent calcitonin and amylin receptor agonist (DACRA). UDA-6 induces weight loss, improves metabolic and hepatic parameters, and stabilizes active receptor states in obesity rats. UDA-6 can be used for the research of obesity.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C193H315N51O62
- 分子量:4341.87
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
UDA-6 (30 min) potently and equally activates human AMY3R and human CTR in HEK-293 cells, with EC50 values of 0.8 pM and 0.6 pM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
UDA-6 (10-20 nmol/kg; s.c.; daily; 24 days) induces body weight decrease and improves metabolic and hepatic parameters in male DIO SD rats[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Lean SD Rats (male, 8-10 weeks old)[1]
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Dosage:1; 3; 10; 30 nmol/kg
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Administration:s.c.; single dose
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Result:Produced a dose-dependent reduction in body weight and cumulative food intake over 96 hours.
Caused transient food intake inhibition over 24 hours followed by rebound at 1 nmol/kg.
Induced a >10% decrease in body weight relative to vehicle controls and sustained food intake suppression over 48 hours at 30 nmol/kg.
Showed no signs of discomfort, emesis, or behavioral abnormalities at any dose.
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Animal Model:DIO SD Rats (male, 600-700 g) maintained on a high fat diet (HFD).[1]
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Dosage:10 ; 20 nmol/kg
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Administration:s.c.; daily; 24 days
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Result:Resulted in a maximum mean body weight decrease of 13.1% from baseline at 20 nmol/kg.
Reduced ad libitum fed blood glucose levels, serum AST, ALT, TG, TC, and fasting blood glucose levels relative to vehicle controls.
Reduced liver weight, hepatic TG, and hepatic TC.
Partially alleviated liver inflammation and lipid deposition via oil red O and H&E staining.
化学情報
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分子量 4341.87
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分子式 C193H315N51O62
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配列
{Pyr}-Ser-His-Leu-Ser-Thr-Ala-Val-Leu-Gly-Arg-cyclo{Lys-(PEG2-Gly-Gly-Ser-Gly-Ser-Gly-γGlu-C20 diacid)-Ser-Ala-Glu-Glu}-His-Lys-Leu-{Aib}-Asp-Tyr-Pro-Arg-Thr-Asp-Val-Gly-Ser-Gly-Ala-Pro-NH2
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シーケンスの短縮
{Pyr}-SHLSTAVLGR-cyclo{K-(PEG2-GGSGSG-γGlu-C20 diacid)-SAEE}-HKL-{Aib}-DYPRTDVGSGAP-NH2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
UDA-6 関連分類
HY-P11830 関連分類
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