UNC7467
Based on 1 Customer Validation
UNC7467 is a potent IP6K inhibitor with values of 4.9, 8.9 and 1320 nM for IP6K2, IP6K1 and IP6K6, respectively. UNC7467 reduces levels of inositol pyrophosphates. UNC7467 can be used for obesity research.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.87%
- CAS 番号: 2922283-43-8
- 分子式: C20H13NO3
- 分子量:315.32
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
IC50: 4.9 nM (IP6K2), 8.9 nM (IP6K1), 1320 nM (IP6K3)[1].
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HCT-116 | EC50 |
0.24 μM
Compound: 20; UNC7467
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Reduction in InsP8-dependent [33P]-inorganic phosphate efflux in human HCT-116 cells measured after 18 hrs by HPLC analysis
Reduction in InsP8-dependent [33P]-inorganic phosphate efflux in human HCT-116 cells measured after 18 hrs by HPLC analysis
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[PMID: 35467861] |
| HCT-116 | EC50 |
1 μM
Compound: 20; UNC7467
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Reduction in InsP8-dependent [33P]-inorganic phosphate efflux in human HCT-116 cells measured after 3 hrs by HPLC analysis
Reduction in InsP8-dependent [33P]-inorganic phosphate efflux in human HCT-116 cells measured after 3 hrs by HPLC analysis
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[PMID: 35467861] |
UNC7467 (2.5 μM; 3 hours; HCT116 cells) reduces levels of inositol pyrophosphates. UNC7467 reduces 5-InsP7 levels by 81% and 5-InsP8 levels by 63%[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
UNC7467 (1-5 mg/kg; i.v. and i.p.; diet-induced obesity mice) exhibits low clearance (13.7 (mL/min)/kg) and large AUClast (6054 h?ng/mL for intra venous (i.v.) and 2527 h?ng/mL for intraperitoneal (i.p.)) in mice at 5 mg/kg dose[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Diet-induced obesity (DIO) mice[1]
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Dosage:5 mg/kg
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Administration:Intraperitoneal injection; daily, for 4 weeks
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Result:Improved glycemic profiles, ameliorated hepatic steatosis, and reduced weight gain without altering food intake.
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Animal Model:Diet-induced obesity (DIO) mice[1]
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Dosage:5 mg/kg (Pharmacokinetic Analysis)
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Administration:Intravenous injection and intraperitoneal injection
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Result:
1.19 route iv ip Dose (mg/kg) 5 5 AUClast (h*ng/mL) 6054 2527 CL (mL/min/kg) 13.7
化学情報
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CAS 番号 2922283-43-8
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性状 Solid
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分子量 315.32
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分子式 C20H13NO3
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Color Light yellow to yellow
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SMILES
O=C(C1=CC2=C(ON=C2C=C1)C3=CC=C(C=C3)C4=CC=CC=C4)O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 14 mg/mL (44.40 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (280 KB)
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- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.1714 mL | 15.8569 mL | 31.7138 mL | 79.2845 mL |
| 5 mM | 0.6343 mL | 3.1714 mL | 6.3428 mL | 15.8569 mL | |
| 10 mM | 0.3171 mL | 1.5857 mL | 3.1714 mL | 7.9285 mL | |
| 15 mM | 0.2114 mL | 1.0571 mL | 2.1143 mL | 5.2856 mL | |
| 20 mM | 0.1586 mL | 0.7928 mL | 1.5857 mL | 3.9642 mL | |
| 25 mM | 0.1269 mL | 0.6343 mL | 1.2686 mL | 3.1714 mL | |
| 30 mM | 0.1057 mL | 0.5286 mL | 1.0571 mL | 2.6428 mL | |
| 40 mM | 0.0793 mL | 0.3964 mL | 0.7928 mL | 1.9821 mL |
UNC7467 関連分類
HY-150607 関連分類
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