VC1052
Based on 1 Customer Validation
VC1052 is a dialkoxypropylammonium-based material and is the core cationic lipid component of the cationic lipid adjuvant Vaxfectin (HY-142998). Vaxfectin consists of VC1052 and lipid DPyPE (HY-112766) in a 1:1 molar ratio. Vaxfectin can be used as a vaccine adjuvant for the preparation of plasmid DNA and protein vaccines.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.72%
- CAS 番号: 370108-98-8
- 分子式: C36H73BrN2O2
- 分子量:645.88
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保管条件:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
VC1052 has a similar structure to GAP-DLRIE and DMRIE, and is a member of the dialkoxypropylamine cationic lipid class[1].
GAP-DLRIE is primarily used to enhance gene transfection efficiency in local tissues (e.g., lungs), but VC1052 does not enhance pDNA transfection in muscle tissue when it forms a complex with the neutral lipid DPyPE at a 1:1 molar ratio. However, it significantly enhances humoral immune responses (antibody titers increased by 20-50 times) by promoting pDNA uptake by antigen presenting cells (APCs) and inducing cytokine secretion (e.g., IL-6) [1].
GAP-DLRIE significantly enhances the delivery efficiency and gene expression level of pDNA in specific tissues (e.g., mouse lungs) by forming a lipoplex with plasmid DNA (pDNA). GAP-DLRIE relies on cationic lipids to bind to the negatively charged phosphate backbone of DNA to form a stable complex that promotes cellular uptake of DNA and protects DNA from nuclease degradation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 370108-98-8
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性状 Liquid
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分子量 645.88
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分子式 C36H73BrN2O2
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Color Colorless to light yellow
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SMILES
CCCC/C=C\CCCCCCCCOCC(C[N+](C)(C)CCCN)OCCCCCCCC/C=C\CCCC.[Br-]
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
DMSO : ≥ 100 mg/mL (154.83 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (265 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.5483 mL | 7.7414 mL | 15.4828 mL | 38.7069 mL |
| 5 mM | 0.3097 mL | 1.5483 mL | 3.0966 mL | 7.7414 mL | |
| 10 mM | 0.1548 mL | 0.7741 mL | 1.5483 mL | 3.8707 mL | |
| 15 mM | 0.1032 mL | 0.5161 mL | 1.0322 mL | 2.5805 mL | |
| 20 mM | 0.0774 mL | 0.3871 mL | 0.7741 mL | 1.9353 mL | |
| 25 mM | 0.0619 mL | 0.3097 mL | 0.6193 mL | 1.5483 mL | |
| 30 mM | 0.0516 mL | 0.2580 mL | 0.5161 mL | 1.2902 mL | |
| 40 mM | 0.0387 mL | 0.1935 mL | 0.3871 mL | 0.9677 mL | |
| 50 mM | 0.0310 mL | 0.1548 mL | 0.3097 mL | 0.7741 mL | |
| 60 mM | 0.0258 mL | 0.1290 mL | 0.2580 mL | 0.6451 mL | |
| 80 mM | 0.0194 mL | 0.0968 mL | 0.1935 mL | 0.4838 mL | |
| 100 mM | 0.0155 mL | 0.0774 mL | 0.1548 mL | 0.3871 mL |
VC1052 関連分類
HY-156616 関連分類
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