VL285 Phenol
Based on 1 Customer Validation
VL285 Phenol is a phenol-based VL285 analog. VL285 is an E3 ubiquitin ligase VHL ligand and can be used in the synthesis of HaloPROTAC3, degrading HaloTag7 fusion protein (IC50=0.34 μM).
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 98.95%
- CAS 番号: 1448188-69-9
- 分子式: C29H32N4O5S
- 分子量:548.65
-
保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
-
溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
生物活性
製品説明
IC50 & Target
|
VHL |
体外実験
VL285 (100 μM; 24 h) attenuates the ability of HaloPROTAC3 to induce the degradation of GFP-HaloTag7[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
-
CAS 番号 1448188-69-9
-
性状 Solid
-
分子量 548.65
-
分子式 C29H32N4O5S
-
Color White to off-white
-
SMILES
CC(N=CS1)=C1C2=CC(O)=C(CNC([C@@H]3C[C@@H](O)CN3C([C@@H](N4CC(C=CC=C5)=C5C4=O)C(C)C)=O)=O)C=C2
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
体外:
DMSO : 100 mg/mL (182.27 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
-
データシート (273 KB)
-
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
-
取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.8227 mL | 9.1133 mL | 18.2266 mL | 45.5664 mL |
| 5 mM | 0.3645 mL | 1.8227 mL | 3.6453 mL | 9.1133 mL | |
| 10 mM | 0.1823 mL | 0.9113 mL | 1.8227 mL | 4.5566 mL | |
| 15 mM | 0.1215 mL | 0.6076 mL | 1.2151 mL | 3.0378 mL | |
| 20 mM | 0.0911 mL | 0.4557 mL | 0.9113 mL | 2.2783 mL | |
| 25 mM | 0.0729 mL | 0.3645 mL | 0.7291 mL | 1.8227 mL | |
| 30 mM | 0.0608 mL | 0.3038 mL | 0.6076 mL | 1.5189 mL | |
| 40 mM | 0.0456 mL | 0.2278 mL | 0.4557 mL | 1.1392 mL | |
| 50 mM | 0.0365 mL | 0.1823 mL | 0.3645 mL | 0.9113 mL | |
| 60 mM | 0.0304 mL | 0.1519 mL | 0.3038 mL | 0.7594 mL | |
| 80 mM | 0.0228 mL | 0.1139 mL | 0.2278 mL | 0.5696 mL | |
| 100 mM | 0.0182 mL | 0.0911 mL | 0.1823 mL | 0.4557 mL |
VL285 Phenol 関連分類
HY-151227 関連分類
Powered by Bioz