VU0155041 sodium
VU0155041 sodium is a potent, selective positive allosteric modulator (PAM) of mGluR4, with EC50s of 798 nM and 693 nM for human and rat mGluR4, respectively. VU0155041 has potential for the research of Parkinson's disease (PD).
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1259372-69-4
- 分子式: C14H14Cl2NNaO3
- 分子量:338.16
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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mGluR4 693 nM (EC50) |
VU0155041 (10 μM) does not affect NMDA receptor currents in striatal medium spiny neurons[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
VU0155041 (93 nmol, 316 nmol; i.c.v.) reverses Reserpine (HY-N0480) -induced akinesia in rats[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Third ventricle cannulated (TVC) Male Sprague-Dawley rats (225-255 g)[1]
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Dosage:31, 93 nmol
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Administration:I.c.v. injection after the the 1.5 mg/kg of haloperidol treatment 2 h
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Result:Decreased the cataleptic effects of haloperidol, and the effects still presented 30 min after infusion.
化学情報
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CAS 番号 1259372-69-4
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分子量 338.16
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分子式 C14H14Cl2NNaO3
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SMILES
O=C([C@H](CCCC1)[C@H]1C(O[Na])=O)NC2=CC(Cl)=CC(Cl)=C2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
VU0155041 sodium 関連分類
HY-14417B 関連分類
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