WAAG-3R
WAAG-3R is a biological active peptide. (Aggrecanases belong to the ADAMTS (A disintegrin and metalloprotease with thrombospondin motif) family of proteases. Aggrecanases cleave aggrecan, the major structural component of cartilage. Aggrecanase-1 (ADAMTS-4) is a major aggrecanase in human osteoarthritic cartilage. This FRET peptide was used in an ADAMTS-4 (Aggrecanase-1) and ADAMTS-5 (Aggrecanase-2) assay. (Ex/Em = 340/420 nm)
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- 分子式: C69H109N23O24
- 分子量:1644.74
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
化学情報
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分子量 1644.74
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分子式 C69H109N23O24
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配列
{Abz}-Thr-Glu-Gly-Glu-Ala-Arg-Gly-Ser-Val-Ile-{Dap(Dnp)}-Lys-Lys-NH2
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シーケンスの短縮
{Abz}-TEGEARGSVI-{Dap(Dnp)}-KK-NH2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. De Savi C, et al. The design and synthesis of novel N-hydroxyformamide inhibitors of ADAM-TS4 for the treatment of osteoarthritis[J]. Bioorganic & medicinal chemistry letters, 2011, 21(5): 1376-1381. [Content Brief]
[2]. Hongfeng Deng, et al. Discovery of highly potent and selective small molecule ADAMTS-5 inhibitors that inhibit human cartilage degradation via encoded library technology (ELT). J Med Chem. 2012 Aug 23;55(16):7061-79. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
WAAG-3R 関連分類
HY-P5419 関連分類
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