WO-459
WO-459 is a potent Gpr52 agonist. WO-459 induces dose-dependent elevation of intracellular cAMP in cells expressing Gpr52. WO-459 can be used for the research of Huntington’s disease and psychotic disorders.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1313195-84-4
- 分子式: C23H20F3N3O2S
- 分子量:459.48
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
WO-459 (Compound 12) (30 min) potently activates human GPR52 expressed in CHO cells with an EC50 of 5.7 nM and an Emax of 102%[1].
WO-459 (1 pM-10 μM) potently activates human Gpr52 in HEK293/hGpr52 cells with an EC50 of 6 nM, increasing intracellular cAMP levels in a dose-dependent manner[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 1313195-84-4
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分子量 459.48
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分子式 C23H20F3N3O2S
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SMILES
O=C(C1=CN(C2=CC=CC3=C2SC(CC4=CC=CC(C(F)(F)F)=C4)=C3)N=C1C)NCCO
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Nakahata T, et al. Design and synthesis of 1-(1-benzothiophen-7-yl)-1H-pyrazole, a novel series of G protein-coupled receptor 52 (GPR52) agonists. Bioorg Med Chem. 2018 May 1;26(8):1598-1608. [Content Brief]
[2]. Song H, et al. Targeting Gpr52 lowers mutant HTT levels and rescues Huntington's disease-associated phenotypes. Brain. 2018;141(6):1782-1798. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
WO-459 関連分類
HY-183945 関連分類
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