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United States

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製品番号: HY-184156

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WSL017

WSL017 is a cytochrome bd oxidase inhibitor with antibacterial activity against Mycobacterium tuberculosis. WSL017 can be used for the research of tuberculosis.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

分子式: C₁₇H₁₉NOS
分子量:285.40

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

WSL017 構造式

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

WSL017 is a cytochrome bd oxidase inhibitor with antibacterial activity against Mycobacterium tuberculosis. WSL017 can be used for the research of tuberculosis^[1].

体外実験

WSL017 (0.001-100 µM) competitively inhibits Mycobacterium tuberculosis cytochrome bd (Mtbd) in proteoliposomes with an IC₅₀ of 1.4 µM by binding to the quinol-binding site^[1].
WSL017 (0.001-100 µM) competitively inhibits Escherichia coli cytochrome bd (Ecbd) in proteoliposomes with an IC₅₀ of 1.7 µM by binding to the quinol-binding site^[1].
WSL017 (3 µM) does not inhibit Caldalkalibacillus thermarum type 2 NADH dehydrogenase (NDH2) activity, confirming its specific action on cytochrome bd oxidases^[1].
WSL017 (100 µM) binds to the quinol oxidation site of dimeric Escherichia coli cytochrome bd (Ecbd) via hydrophobic interactions, stabilizing the Q-loop in a closed state to inhibit enzyme activity^[1].
WSL017 (25 µM; 7 days) significantly impairs the growth of Mycobacterium tuberculosis H37ra cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

Mycobacterium tuberculosis H37ra cells
Concentration:

25 µM
Incubation Time:

7 days
Result:

Reduced growth to approximately 50% relative to control.
Significantly impaired the growth of Mycobacterium tuberculosis H37ra cells.

Related Protocols :

化学情報

分子量 285.40
分子式 C₁₇H₁₉NOS
SMILES

CCC(NC1=CC=C(SC2=CC(C)=CC=C2C)C=C1)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (268 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Tijn T. van der Velden, et al. Discovery of a novel chemotype targeting Mycobacterium tuberculosis cytochrome bd through rapid screening and structural elucidation. bioRxiv. 2026.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

MOQ

Minimum order quantity

100 mg

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