XR5944
Based on 1 Customer Validation
XR5944 is an anti-tumor compound with DNA-targeting activity. As a topoisomerase inhibitor, XR5944 can effectively inhibit the activities of topoisomerase I and II. XR5944 shows excellent anti-tumor activity against human and mouse tumor cells in vitro and in vivo. XR5944 exhibits significant potency in multiple cell lines, with IC50 values of 0.04-0.4 nM. XR5944 is not affected by atypical drug resistance in cells and remains significantly active even in cells overexpressing P-glycoprotein or multidrug resistance-related proteins. XR5944 showed anti-tumor efficacy in human tumor models of H69 small cell lung cancer and HT29 colon cancer, inducing tumor regression in most animals in the HT29 model. XR5944 can be used to study biological processes related to colon and lung cancer.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 97.39%
- CAS 番号: 343247-32-5
- 分子式: C34H34N8O2
- 分子量:586.69
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
Endogenous Metabolite アイソフォーム固有の製品をすべて表示
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生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CAKI-1 | GI50 |
<10 nM
Compound: 8
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Inhibitory concentration required to reduce cell growth to 50% of control cultures in the CAK1 human cell line
Inhibitory concentration required to reduce cell growth to 50% of control cultures in the CAK1 human cell line
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[PMID: 11311063] |
| D3F | IC50 |
4.4 nM
Compound: 8
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Concentration of the drug to reduce cell number to 50% of controls in D3F cell line
Concentration of the drug to reduce cell number to 50% of controls in D3F cell line
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[PMID: 11311063] |
| HCT-116 | GI50 |
<10 nM
Compound: 8
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Inhibitory concentration required to reduce cell growth to 50% of control cultures in the HTC116 human cell line
Inhibitory concentration required to reduce cell growth to 50% of control cultures in the HTC116 human cell line
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[PMID: 11311063] |
| HT-29 | GI50 |
<10 nM
Compound: 8
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Inhibitory concentration required to reduce cell growth to 50% of control cultures in the HT-29 human cell line
Inhibitory concentration required to reduce cell growth to 50% of control cultures in the HT-29 human cell line
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[PMID: 11311063] |
| HT-29 | IC50 |
0.08 nM
Compound: 8
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Inhibitory concentration of the drug resulting in inhibition of cell growth to 50% of controls in HT-29 (human colon)
Inhibitory concentration of the drug resulting in inhibition of cell growth to 50% of controls in HT-29 (human colon)
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[PMID: 11311063] |
| Lewis lung carcinoma cell line | IC50 |
2.8 nM
Compound: 8
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Inhibitory concentration required to reduce cell number to 50% of control cultures in LL(Lewis lung carcinoma cell line)
Inhibitory concentration required to reduce cell number to 50% of control cultures in LL(Lewis lung carcinoma cell line)
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[PMID: 11311063] |
| MCF7 | GI50 |
<10 nM
Compound: 8
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Inhibitory concentration required to reduce cell growth to 50% of control cultures in the MCF-7 human cell line
Inhibitory concentration required to reduce cell growth to 50% of control cultures in the MCF-7 human cell line
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[PMID: 11311063] |
| MOLT-4 | IC50 |
0.0062 nM
Compound: 8
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Inhibitory concentration of the drug resulting in inhibition of cell growth to 50% of controls in MOLT-4 (human leukemia)
Inhibitory concentration of the drug resulting in inhibition of cell growth to 50% of controls in MOLT-4 (human leukemia)
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[PMID: 11311063] |
| P388 | IC50 |
21 nM
Compound: 8
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Inhibitory concentration required to reduce cell number to 50% of control cultures in P388 (murine leukemia cell line)
Inhibitory concentration required to reduce cell number to 50% of control cultures in P388 (murine leukemia cell line)
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[PMID: 11311063] |
| SK-OV-3 | GI50 |
<10 nM
Compound: 8
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Inhibitory concentration required to reduce cell growth to 50% of control cultures in the SKOV3 human cell line
Inhibitory concentration required to reduce cell growth to 50% of control cultures in the SKOV3 human cell line
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[PMID: 11311063] |
| U-937 | IC50 |
0.047 nM
Compound: 8
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Inhibitory concentration of the drug resulting in inhibition of cell growth to 50% of controls in U937 (human leukemia)
Inhibitory concentration of the drug resulting in inhibition of cell growth to 50% of controls in U937 (human leukemia)
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[PMID: 11311063] |
化学情報
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CAS 番号 343247-32-5
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性状 Solid
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分子量 586.69
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分子式 C34H34N8O2
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Color Light yellow to yellow
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SMILES
O=C(C1=CC=CC2=NC3=CC=CC(C)=C3N=C21)NCCNCCNCCNC(C4=CC=CC5=NC6=CC=CC(C)=C6N=C54)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
純度とドキュメンテーション
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データシート (266 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
XR5944 関連分類
HY-118899 関連分類
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