XYD129
XYD129 is an effective CBP/p300 PROTAC degrader. XYD129 has antiproliferative activity on MV4-11 cell line (IC 50=0.044 μM). XYD129 can be used for the study of acute myeloid leukemia (AML). (Structure Note: Pink, CBP/p300 ligand 5 (HY-161711); Blue, E3 ligase ligand (HY-41547); Black, Linker (HY-40178)).
(Pink: Epigenetic Reader Domain ligand (HY-161711); Blue: Cereblon ligand (HY-41547); Black: linker (HY-40178)).
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C41H39FN8O9
- 分子量:806.79
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| KG-1 | IC50 |
0.57 μM
Compound: 11c
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Antiproliferative activity against human KG-1 cells assessed as inhibition of cell growth incubated for 72 hrs by celltiter glo luminescence analysis
Antiproliferative activity against human KG-1 cells assessed as inhibition of cell growth incubated for 72 hrs by celltiter glo luminescence analysis
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[PMID: 38829718] |
| L02 | IC50 |
>100 μM
Compound: 11c
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Cytotoxicity against human HL7702 cells assessed as inhibition of cell growth incubated for 72 hrs by celltiter glo luminescence analysis
Cytotoxicity against human HL7702 cells assessed as inhibition of cell growth incubated for 72 hrs by celltiter glo luminescence analysis
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[PMID: 38829718] |
| MOLM-16 | IC50 |
0.007 μM
Compound: 11c
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Antiproliferative activity against human MOLM16 cells assessed as inhibition of cell growth incubated for 72 hrs by celltiter glo luminescence analysis
Antiproliferative activity against human MOLM16 cells assessed as inhibition of cell growth incubated for 72 hrs by celltiter glo luminescence analysis
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[PMID: 38829718] |
| MV4-11 | IC50 |
0.044 μM
Compound: 11c
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Antiproliferative activity against human MV4-11 cells assessed as inhibition of cell growth incubated for 120 hrs by celltiter glo luminescence analysis
Antiproliferative activity against human MV4-11 cells assessed as inhibition of cell growth incubated for 120 hrs by celltiter glo luminescence analysis
|
[PMID: 38829718] |
化学情報
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分子量 806.79
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分子式 C41H39FN8O9
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SMILES
O=C(C1=CC(C(NC2=C(C(C3=CN(N=C3)C)=CC(CO)=C2)F)=O)=C4N1C=CC(OCC(NCCCCNC5=CC=CC6=C5C(N(C7CCC(NC7=O)=O)C6=O)=O)=O)=C4)C
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
XYD129 関連分類
HY-161710 関連分類
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