YE120
Based on 1 Customer Validation
YE120 is a potent GPR35 agonist with an EC50 of 32.5 nM.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.93%
- CAS 番号: 383124-82-1
- 分子式: C16H9Cl2N3O
- 分子量:330.17
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保管条件:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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Bioactive Compound Library Max
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MCE Bioactive Compound Library
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Bioactive Compound Library
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Lactylation Compound Library
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生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HT-29 | EC50 |
0.032 μM
Compound: 1, YE120
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Agonist activity at GPR35 in human HT-29 cells after 1 hr by dynamic mass redistribution assay
Agonist activity at GPR35 in human HT-29 cells after 1 hr by dynamic mass redistribution assay
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[PMID: 21950657] |
| HT-29 | IC50 |
0.06 μM
Compound: 1, YE120
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Agonist activity at GPR35 in human HT-29 cells assessed as desensitization of 1 uM zaprinast-induced DMR after 1 hr by dynamic mass redistribution assay
Agonist activity at GPR35 in human HT-29 cells assessed as desensitization of 1 uM zaprinast-induced DMR after 1 hr by dynamic mass redistribution assay
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[PMID: 21950657] |
| U2OS | EC50 |
10.2 μM
Compound: 1, YE120
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Agonist activity at GPR35 in human U20S cells expressing beta-lactamase and GPR35-GA14-VP16 transcription factor fusion protein assessed as transcriptional activation after 5 hrs by tango beta-arrestin translocation reporter assay
Agonist activity at GPR35 in human U20S cells expressing beta-lactamase and GPR35-GA14-VP16 transcription factor fusion protein assessed as transcriptional activation after 5 hrs by tango beta-arrestin translocation reporter assay
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[PMID: 21950657] |
化学情報
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CAS 番号 383124-82-1
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性状 Solid
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分子量 330.17
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分子式 C16H9Cl2N3O
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Color White to off-white
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SMILES
N#C/C(C#N)=C1OC(C(C)=C/1C#N)(C)C2=CC=C(C(Cl)=C2)Cl
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
DMSO : 33 mg/mL (99.95 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.0287 mL | 15.1437 mL | 30.2874 mL | 75.7186 mL |
| 5 mM | 0.6057 mL | 3.0287 mL | 6.0575 mL | 15.1437 mL | |
| 10 mM | 0.3029 mL | 1.5144 mL | 3.0287 mL | 7.5719 mL | |
| 15 mM | 0.2019 mL | 1.0096 mL | 2.0192 mL | 5.0479 mL | |
| 20 mM | 0.1514 mL | 0.7572 mL | 1.5144 mL | 3.7859 mL | |
| 25 mM | 0.1211 mL | 0.6057 mL | 1.2115 mL | 3.0287 mL | |
| 30 mM | 0.1010 mL | 0.5048 mL | 1.0096 mL | 2.5240 mL | |
| 40 mM | 0.0757 mL | 0.3786 mL | 0.7572 mL | 1.8930 mL | |
| 50 mM | 0.0606 mL | 0.3029 mL | 0.6057 mL | 1.5144 mL | |
| 60 mM | 0.0505 mL | 0.2524 mL | 0.5048 mL | 1.2620 mL | |
| 80 mM | 0.0379 mL | 0.1893 mL | 0.3786 mL | 0.9465 mL |
YE120 関連分類
HY-107538 関連分類
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