YM511
Based on 1 Customer Validation
YM511 is a highly specific non-steroidal aromatase inhibitor. YM511 inhibits aromatase activities in microsomes from rat ovary and human placenta competitively (IC50s of 0.4 and 0.12 nM, respectively). YM511 slightly inhibits production of other steroid hormones. YM511 has the potential for suppressing estrogen-dependent action research without affecting serum levels of other steroid hormones.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.73%
- CAS 番号: 148869-05-0
- 分子式: C16H12BrN5
- 分子量:354.20
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保管条件:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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Highly Selective Inhibitors Library
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Radioprotector Library
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Bioactive Compound Library Max
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MCE Bioactive Compound Library
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Drug Repurposing Compound Library Plus
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Clinical Compound Library Plus
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Bioactive Compound Library
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High-Throughput Bioactive Compound Library
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Metabolism/Protease Compound Library
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Clinical Compound Library
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Anti-Aging Compound Library
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Drug Repurposing Compound Library
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生物活性
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Aromatase |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| JEG-3 | IC50 |
0.5 nM
Compound: 1
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Inhibition of aromatase in human JEG-3 cells using [1beta-3H]androstenedione after 1 hr by scintillation spectrometry
Inhibition of aromatase in human JEG-3 cells using [1beta-3H]androstenedione after 1 hr by scintillation spectrometry
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[PMID: 24900302] |
| JEG-3 | IC50 |
0.5 nM
Compound: 1
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Inhibition of aromatase in JEG3 cell membrane
Inhibition of aromatase in JEG3 cell membrane
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[PMID: 17580845] |
化学情報
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CAS 番号 148869-05-0
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性状 Solid
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分子量 354.20
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分子式 C16H12BrN5
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Color Off-white to light yellow
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SMILES
BrC(C=C1)=CC=C1CN(N2C=NN=C2)C3=CC=C(C#N)C=C3
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶剤 & 溶解度
DMSO : 250 mg/mL (705.82 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (274 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.8233 mL | 14.1163 mL | 28.2326 mL | 70.5816 mL |
| 5 mM | 0.5647 mL | 2.8233 mL | 5.6465 mL | 14.1163 mL | |
| 10 mM | 0.2823 mL | 1.4116 mL | 2.8233 mL | 7.0582 mL | |
| 15 mM | 0.1882 mL | 0.9411 mL | 1.8822 mL | 4.7054 mL | |
| 20 mM | 0.1412 mL | 0.7058 mL | 1.4116 mL | 3.5291 mL | |
| 25 mM | 0.1129 mL | 0.5647 mL | 1.1293 mL | 2.8233 mL | |
| 30 mM | 0.0941 mL | 0.4705 mL | 0.9411 mL | 2.3527 mL | |
| 40 mM | 0.0706 mL | 0.3529 mL | 0.7058 mL | 1.7645 mL | |
| 50 mM | 0.0565 mL | 0.2823 mL | 0.5647 mL | 1.4116 mL | |
| 60 mM | 0.0471 mL | 0.2353 mL | 0.4705 mL | 1.1764 mL | |
| 80 mM | 0.0353 mL | 0.1765 mL | 0.3529 mL | 0.8823 mL | |
| 100 mM | 0.0282 mL | 0.1412 mL | 0.2823 mL | 0.7058 mL |
YM511 関連分類
HY-105184 関連分類
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