Zelicapavir
Based on 1 publication(s) in Google Scholar
Zelicapavir (RSV-IN-7) (example 253) is an orally active RSV inhibitor (EC50: < 0.4 μΜ).
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.10%
- CAS 番号: 2070852-76-3
- 分子式: C27H22F3N7O3
- 分子量:549.50
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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MedChemExpress（MCE）の使用を引用している文献 Zelicapavir
More
生物活性
製品説明
IC50 & Target
RSV[1]
体外実験
Zelicapavir inhibits RSV strains RSV-A Long, RSV-A2, RSV-A M37, RSV-B VR-955 in cells Hep-2, A549, Vero, HBEC, reduces the level of viral RNA in RSV-infected cells with EC50s in nanomolar levels[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Hep-2, A549, Vero, HBEC
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Concentration:
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Incubation Time:6 days
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Result:Inhibited viral RNA levels.
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:RSV-infected african green monkey model[2]
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Dosage:100 mg/kg
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Administration:po, twice a day for 6 days
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Result:Reduced the viral load in the bronchoalveolar lavage (BAL) fluid.
臨床実験
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
化学情報
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CAS 番号 2070852-76-3
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性状 Solid
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分子量 549.50
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分子式 C27H22F3N7O3
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Color Light yellow to yellow
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SMILES
FC(F)(C1=CC(N2CCOCC2)=C(C3=NN=C(N[C@H]4N=C(C5=CC=CC=C5)C6=CC=CC=C6NC4=O)O3)N=C1)F
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別名
EDP-938; RSV-IN-7
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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mBio
A new mechanism of respiratory syncytial virus entry inhibition by small-molecule to overcome K394R-associated resistance. [Abstract]2024 Sep 11;15(9):e0138524. PMID: 39162560
溶剤 & 溶解度
体外:
DMSO : 50 mg/mL (90.99 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (279 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.8198 mL | 9.0992 mL | 18.1984 mL | 45.4959 mL |
| 5 mM | 0.3640 mL | 1.8198 mL | 3.6397 mL | 9.0992 mL | |
| 10 mM | 0.1820 mL | 0.9099 mL | 1.8198 mL | 4.5496 mL | |
| 15 mM | 0.1213 mL | 0.6066 mL | 1.2132 mL | 3.0331 mL | |
| 20 mM | 0.0910 mL | 0.4550 mL | 0.9099 mL | 2.2748 mL | |
| 25 mM | 0.0728 mL | 0.3640 mL | 0.7279 mL | 1.8198 mL | |
| 30 mM | 0.0607 mL | 0.3033 mL | 0.6066 mL | 1.5165 mL | |
| 40 mM | 0.0455 mL | 0.2275 mL | 0.4550 mL | 1.1374 mL | |
| 50 mM | 0.0364 mL | 0.1820 mL | 0.3640 mL | 0.9099 mL | |
| 60 mM | 0.0303 mL | 0.1517 mL | 0.3033 mL | 0.7583 mL | |
| 80 mM | 0.0227 mL | 0.1137 mL | 0.2275 mL | 0.5687 mL |
Zelicapavir 関連分類
HY-147346 関連分類
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