Zoxamide
Based on 1 Customer Validation
Zoxamide (RH-7281) is an oomycete Fungicide and covalent β-tubulin inhibitor. RH-7281 inhibits the assembly of tubulin into microtubules in vitro. Zoxamide binds covalently to β-tubulin, disrupting microtubule assembly and the cytoskeleton. Zoxamide blocks nuclear division in germinated hyphae of Phytophthora capsici and inhibits hyphal growth of Phytophthora capsici.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.05%
- CAS 番号: 156052-68-5
- 分子式: C14H16Cl3NO2
- 分子量:336.64
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
Studies show that all field-collected isolates of Phytophthora cactorum are sensitive to zoxamide (0.02-1.0 mg/L; 6 days), with a mean EC50 value of 0.14 mg/L for inhibiting radial mycelial growth[1].
Zoxamide (0-1 ppm) rapidly and potently inhibits nuclear division in Phytophthora capsici seedlings[2].
Zoxamide (0.05 ppm; 30 min) completely disrupts the microtubule cytoskeleton in germ tubes of *Phytophthora capsici*, eliminating detectable microtubule filaments[2].
Zoxamide (5-30 μM; 1-8 h) inhibits in vitro microtubule assembly of tubulin isolated from bovine brain in a dose-dependent manner, and its inhibitory potency increases with prolonged pre-incubation time[2].
Zoxamide (16 h) potently inhibits the mycelial growth of *Phytophthora capsici* in microtiter plate assays, with an EC50 of 0.0031 ppm[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 156052-68-5
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性状 Solid
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分子量 336.64
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分子式 C14H16Cl3NO2
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Color White to off-white
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SMILES
O=C(NC(C)(CC)C(CCl)=O)C1=CC(Cl)=C(C)C(Cl)=C1
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別名
RH-7281
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
純度とドキュメンテーション
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データシート (267 KB)
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SDS (537 KB)
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取扱説明書 (2659 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Zoxamide 関連分類
HY-120921 関連分類
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