CHNQD-01255
CHNQD-01255 is an orally active Arf-GEFs inhibitor with potent anti-hepatocellular carcinoma (HCC) efficacy.
For research use only. We do not sell to patients.
- CAS No.: 2756173-91-6
- Formula: C23H29NO6
- Molecular Weight:415.48
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| Bel-7402 | IC50 |
0.07 μM
Compound: 16; CHNQD-01255
|
Antiproliferative activity against human Bel-7402 cells by MTT assay
Antiproliferative activity against human Bel-7402 cells by MTT assay
|
[PMID: 36089748] |
| HepG2 | IC50 |
0.1 μM
Compound: 16; CHNQD-01255
|
Antiproliferative activity against human HepG2 cells by MTT assay
Antiproliferative activity against human HepG2 cells by MTT assay
|
[PMID: 36089748] |
CHNQD-01255 (0-1 μM approximately, 72 h) inhibits HepG2 and BEL-7402 cell proliferation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:HepG2, BEL-7402 cell
-
Concentration:0-1 μM approximately
-
Incubation Time:72 h
-
Result:Inhibited cell proliferation with an IC50 value of 0.1 μM (HepG2) and 0.07 μM (BEL-7402).
CHNQD-01255 exhibits a high safety profile with MTD values exceeding 750 and 100 mg/kg for p.o. and i.p. administrations in mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:HepG2 tumor-bearing xenograft mice[1]
-
Dosage:5, 15, and 45 mg/kg
-
Administration:Oral adminstration (p.o.), every day for 21 consecutive days.
-
Result:Resulted in dramatically delayed tumor progression, with a tumor growth inhibition rate (TGI %) value of 61.0% at 45 mg/kg.
-
Animal Model:HepG2 tumor-bearing xenograft mice[1]
-
Dosage:1 and 9 mg/kg
-
Administration:Intraperitoneal injection (i.p.), every day for 21 consecutive days.
-
Result:Inhibited the tumor growth with the TGI values of 36.6 and 48.3%, respectively.
-
Animal Model:Mice (Pharmacokinetic assay)[1]
-
Dosage:45 mg/kg p.o., 10 mg/kg i.v.
-
Administration:Oral adminstration (p.o.) or intravenous injection (i.v.)
-
Result:Pharmacokinetic profile of CHNQD-01255.
dose (mg/kg) T1/2 (h) Cmax (ng/mL) Cl (mL/h/kg) F (%) 45 (p.o.) 7.35 20.26 598245.37 2.26 10 (i.v.) 2060.78
Chemical Information
-
CAS No. 2756173-91-6
-
Molecular Weight 415.48
-
Formula C23H29NO6
-
SMILES
O[C@H]1[C@@]2([H])[C@@](/C=C/CCC[C@@H](OC(/C=C/1)=O)C)([H])C[C@@H](C2)OC(OCC3=CN=CC=C3)=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz