Sonchuside A
Sonchuside A ((+)-Sonchuside A) is a sesquiterpene lactone found in the roots of Taraxacum obovatum and Taraxacum bicorne. Terpenes are the most numerous and structurally diverse natural products found in many plants. In vitro, preclinical, and clinical studies have demonstrated that terpenes exhibit broad and important pharmacological properties in the treatment of cancer, malaria, inflammation, and various infectious diseases.
For research use only. We do not sell to patients.
- CAS No.: 111618-82-7
- Formula: C21H32O8
- Molecular Weight:412.47
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
Sonchuside A is isolated from Taraxacum obovatum roots with a yield of 2.0 mg, and its identity is confirmed via HPLC, 1H NMR, and specific optical rotation matching to known reference samples[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 111618-82-7
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Molecular Weight 412.47
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Formula C21H32O8
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SMILES
C[C@H]1[C@@](CC/C(C)=C\C[C@@H]2O[C@@H]([C@@H]([C@H]3O)O)O[C@@H]([C@H]3O)CO)([H])[C@@](OC1=O)([H])/C=C2/C
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Synonyms
(+)-Sonchuside A
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Research Protocol for Inflammation-related Diseases
The NLRP3 inflammasome is a cytosolic innate immune signaling platform that integrates priming signals and danger-signal activation to promote caspase-1 activation, maturation of IL-1β and IL-18, and gasdermin D-mediated pyroptotic cell death. The core experimental logic is to determine whether inflammatory disease phenotypes are driven by increased NLRP3 expression, ASC-containing inflammasome assembly, caspase-1 cleavage, GSDMD cleavage, and extracellular release of IL-1β/IL-18 rather than by nonspecific cell injury alone. The pathway is strongly linked to inflammation-related disease phenotypes because monosodium urate crystals activate NALP3/NLRP3 inflammasome signaling in gout-like crystal inflammation, cholesterol crystals activate NLRP3 inflammasomes in atherogenesis models, and DSS-induced intestinal inflammation has been reported to involve NLRP3 inflammasome activity. However, experimental colitis studies also show context-dependent protective effects of NLRP3 inflammasome co
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Sonchuside A Related Classifications
HY-N19112 Related Classifications
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