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Cat. No.: HY-187348

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TT-03597

TT-03597 is a modified NAMPT inhibitor core derived from OT-82 (HY-136241), which serves as a target protein ligand for PROTACs targeting NAMPT. TT-03597 can be used for the synthesis of PROTAC NAMPT Degrader-31 (HY-187347).

For research use only. We do not sell to patients.

CAS No.: 1800487-38-0
Formula: C₂₅H₂₆FN₅O
Molecular Weight:431.51

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

TT-03597 Chemical Structure

CAS No.: 1800487-38-0

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
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Biological Activity

Description

In Vitro

TT-03597 serves as the target protein ligand for PROTAC NAMPT Degrader-31 (HY-187347)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1800487-38-0
Molecular Weight 431.51
Formula C₂₅H₂₆FN₅O
SMILES

O=C(NCCCC1=CNN=C1)C(C=C2C#CC3=CC=C(C=C3)F)=CC=C2N4CCNCC4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Song Y, et al. Discovery of a Potent NAMPT-Targeting PROTAC for the Suppression of Triple-Negative Breast Cancer via Macrophage Reprogramming. Journal of medicinal chemistry. 2026 Jul 23;69(14):16801-16818. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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