1-Hexanol
Based on 1 Customer Validation
1-Hexanol, a primary alcohol, is a surfactant that can be employed in industrial processes to enhance interfacial properties. 1-Hexanol uncouples mitochondrial respiration by a non-protonophoric mechanism.
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- Purity: 99.35%
- CAS No.: 111-27-3
- 화학식: C6H14O
- 분자량:102.18
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보관:
Store at room temperature 3 years.
In solvent -80°C, 2 years , -20°C, 1 year
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Biological Activity
1-Hexanol (0-16 µmol/mg mitochondrial protein) dose-dependently modulates mitochondrial respiration, affects the membrane potential, and exhibits uncoupling effect by affecting the pump function of the mitochondrial respiratory chain[2].
1-Hexanol (0-20 mM) activates S1 Mg-ATPase, increases the affinity of S1 for actin with the presence of ATP[3].
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MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sprague-Dawley rats[1]
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Dosage:50-100 mg/kg
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Administration:ip, single dose
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Result:Increased the secretion of prolactin and ACTH.
Chemical Information
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CAS No. 111-27-3
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Appearance Liquid (Density: 0.820 g/cm3)
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분자량 102.18
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화학식 C6H14O
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Color Colorless to light yellow
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SMILES
OCCCCCC
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Initial Source
Alfalfa Plant Bug
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Store at room temperature 3 years
In solvent -80°C 2 years -20°C 1 year
용액&용해도
Ethanol : 100 mg/mL (978.67 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% EtOH 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (24.47 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% EtOH 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (24.47 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Add each solvent one by one: 10% EtOH 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (24.47 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
순도&문서
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Data Sheet (267 KB)
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SDS (605 KB)
- English - EN (605 KB)
- Français - FR (605 KB)
- Deutsch - DE (605 KB)
- Norwegian - NO (605 KB)
- Español - ES (605 KB)
- Swedish - SV (605 KB)
- Italian - IT (605 KB)
- Korean - KR (605 KB)
- Portuguese - PT (605 KB)
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Handling Instructions (2659 KB)
References
[1]. Cuong V Nguyen, et al. Surface potential of 1-hexanol solution: comparison with methyl isobutyl carbinol. J Phys Chem B. 2013 Jun 27;117(25):7615-20. [Content Brief]
[2]. M Canton, et al. The nature of uncoupling by n-hexane, 1-hexanethiol and 1-hexanol in rat liver mitochondria. Biochim Biophys Acta. 1996 May 20;1274(1-2):39-47. [Content Brief]
[3]. Komatsu H, et al., Modulation of actomyosin motor function by 1-hexanol. J Muscle Res Cell Motil. 2004;25(1):77-85 [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| Ethanol | 1 mM | 9.7867 mL | 48.9333 mL | 97.8665 mL | 244.6663 mL |
| 5 mM | 1.9573 mL | 9.7867 mL | 19.5733 mL | 48.9333 mL | |
| 10 mM | 0.9787 mL | 4.8933 mL | 9.7867 mL | 24.4666 mL | |
| 15 mM | 0.6524 mL | 3.2622 mL | 6.5244 mL | 16.3111 mL | |
| 20 mM | 0.4893 mL | 2.4467 mL | 4.8933 mL | 12.2333 mL | |
| 25 mM | 0.3915 mL | 1.9573 mL | 3.9147 mL | 9.7867 mL | |
| 30 mM | 0.3262 mL | 1.6311 mL | 3.2622 mL | 8.1555 mL | |
| 40 mM | 0.2447 mL | 1.2233 mL | 2.4467 mL | 6.1167 mL | |
| 50 mM | 0.1957 mL | 0.9787 mL | 1.9573 mL | 4.8933 mL | |
| 60 mM | 0.1631 mL | 0.8156 mL | 1.6311 mL | 4.0778 mL | |
| 80 mM | 0.1223 mL | 0.6117 mL | 1.2233 mL | 3.0583 mL | |
| 100 mM | 0.0979 mL | 0.4893 mL | 0.9787 mL | 2.4467 mL |
1-Hexanol Related Classifications
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