16:0 DAP
Based on 1 Customer Validation
16:0 DAP is an ionizable cationic lipid. 1,2-dipalmitoyl-3-dimethylammonium-propane serves as a barcode lipid, enabling LC-MS quantification in ocular tissues.
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- Purity : 99%
- CAS No.: 96326-74-8
- 화학식: C37H73NO4
- 분자량:595.98
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보관:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
In Vitro
16:0 DAP (100 ng/g) is successfully detected from bovine vitreous and neural retina with no remarkable background using LC-MS[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Parmacokinetics
| Species | Dose | Route | C0 | T1/2 | MRT | Vd | AUC0-inf |
|---|---|---|---|---|---|---|---|
| Rat[1] | 0.162 ug | i.v. | 2822 ng/mL | 3.70 day | 5.33 day | 0.0574 mL | 6982 ng·day/mL |
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Wistar (male, 12-week-old)[1]
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Dosage:36000 ng/mL
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Administration:intravitreal injection; single dose
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Result:Achieved a mean liposome size of 169 nm (SD 78), a zeta potential of 8.2 mV, and a particle concentration of 1.5 × 1013 particles/mL.
Showed no decrease in vitreous concentration over 6 days.
Was not observed in the aqueous humor.
Resulted in a neural retina AUC of 2034 (ng*day)/g.
Achieved a neural retina-to-vitreous concentration ratio of 203.6% on day 0, 17.5% on day 1, and 4.0% on day 6.
Showed a maximum retinal bioavailability of 6-16%.
Chemical Information
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CAS No. 96326-74-8
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Appearance Solid
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분자량 595.98
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화학식 C37H73NO4
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Color White to off-white
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SMILES
O=C(CCCCCCCCCCCCCCC)OCC(CN(C)C)OC(CCCCCCCCCCCCCCC)=O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
In Vitro:
DMSO : 11.11 mg/mL (18.64 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (267 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.6779 mL | 8.3895 mL | 16.7791 mL | 41.9477 mL |
| 5 mM | 0.3356 mL | 1.6779 mL | 3.3558 mL | 8.3895 mL | |
| 10 mM | 0.1678 mL | 0.8390 mL | 1.6779 mL | 4.1948 mL | |
| 15 mM | 0.1119 mL | 0.5593 mL | 1.1186 mL | 2.7965 mL |
16:0 DAP Related Classifications
HY-144022 Related Classifications
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