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4μ8C

(Synonyms: IRE1 Inhibitor III)
74 Cited Publications
고객리뷰

Based on 74 publication(s) in Google Scholar

4μ8C (IRE1 Inhibitor III) is a small-molecule inhibitor of IRE1α.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

  • Purity: 99.95%
  • CAS No.: 14003-96-4
  • 화학식: C11H8O4
  • 분자량:204.18
  • 보관:
    Powder   -20°C, 3 years ; In solvent   -80°C, 1 year , -20°C, 6 months
  • 4μ8C Chemical Structure
    4μ8C Chemical Structure
  • Experimental Validation Results for 4μ8C
  • Experimental Validation Results for 4μ8C
  • Experimental Validation Results for 4μ8C
  • Experimental Validation Results for 4μ8C
  • Experimental Validation Results for 4μ8C
  • Experimental Validation Results for 4μ8C
CAS No.: 14003-96-4
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  • 4μ8C Chemical Structure
    4μ8C Chemical Structure
    1/16
  • 1/16

    4μ8C purchased from MedChemExpress. Usage Cited in: Immunity. 2025 Aug 22:S1074-7613(25)00332-2. [Abstract]

    Customer Validation
     Representative images of mouse colon organoids treated with G'9668 or 4μ8C (10 μM) for 24 h after being differentiated with DAPT for 5 days. Scale bars, 360 μm.

  • 1/16

    4μ8C purchased from MedChemExpress. Usage Cited in: Immunity. 2025 Aug 22:S1074-7613(25)00332-2. [Abstract]

    Customer Validation
     Graphs depicting relative mRNA expression of Muc2 in colon organoids treated with G'9668 or 4μ8C (10 μM) for 24 h after incubation, with or without DAPT for 5 days, measured by RT-qPCR.

  • 1/16

    4μ8C purchased from MedChemExpress. Usage Cited in: Immunity. 2025 Aug 22:S1074-7613(25)00332-2. [Abstract]

    Customer Validation
     Graphs depicting relative mRNA expression of Agr2 in colon organoids treated with G'9668 or 4μ8C (10 μM) for 24 h after incubation, with or without DAPT for 5 days, measured by RT-qPCR.

  • 1/16

    4μ8C purchased from MedChemExpress. Usage Cited in: Nat Metab. 2024 Aug;6(8):1601-1615. [Abstract]

    Customer Validation
     Xbp1 splicing and Gcg expression in NaHS-treated cells in the presence of 60 μM 4μ8c for 2h (n = 4 for all groups).

  • 1/16

    4μ8C purchased from MedChemExpress. Usage Cited in: Environ Toxicol. 2023 Jul;38(7):1756-1767. [Abstract]

    Customer Validation
     4μ8C (20 μM; 1 h) significantly inhibits NaF-induced increased expression of p-IRE1 , GRP78 , p-TRAF2 , p-JNK, and LC3II/I in LS8 cells.

  • 1/16

    4μ8C purchased from MedChemExpress. Usage Cited in: Toxins. 2020 Jan 16;12(1):55. [Abstract]

    Customer Validation
     The effect of the IRE1 specific inhibitor 4μ8C on the expression of apoptosis-related proteins. The cells are exposed to FB1 with or without 4μ8C for 24 h, and the phosphorylation of JNK, Mcl-1, Bak, Bax, and Puma were analyzed by Western blotting. n = 3.

  • 4μ8C