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Cat. No.: HY-111369

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CHK1-IN-2

CHK1-IN-2 is a checkpoint kinase 1 (CHK1) inhibitor, with an IC₅₀ of 6 nM.

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CAS No.: 912367-45-4
화학식: C₂₀H₂₂N₄OS
분자량:366.48

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

CHK1-IN-2 Chemical Structure

CAS No.: 912367-45-4

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

CHK1-IN-2 is a checkpoint kinase 1 (CHK1) inhibitor, with an IC₅₀ of 6 nM.

IC₅₀ & Target^[1]

Chk1

6 nM (IC₅₀)

All Checkpoint Kinase (Chk) Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
MDA-MB-231	GI₅₀	306 nM Compound: 44	Antiproliferative activity against human MDA-MB-231 cells Antiproliferative activity against human MDA-MB-231 cells	[PMID: 29301085]
NCI-H460	GI₅₀	2453 nM Compound: 44	Antiproliferative activity against human H460 cells harboring dominant negative p53 construct Antiproliferative activity against human H460 cells harboring dominant negative p53 construct	[PMID: 29301085]
SW-620	GI₅₀	725 nM Compound: 44	Antiproliferative activity against human SW620 cells Antiproliferative activity against human SW620 cells	[PMID: 29301085]

In Vitro

CHK1-IN-2 is a checkpoint kinase 1 (CHK1) inhibitor, with an IC₅₀ of 6 nM, which is a potential cancer therapeutic that can be utilized for enhancing the efficacy of DNA damaging agents^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 912367-45-4
분자량 366.48
화학식 C₂₀H₂₂N₄OS
SMILES

O=C(N)C1=C(SC(C2=CC=CC=C2)=C3)C3=C(N[C@@H]4[C@@H](C)NCCC4)N=C1
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Yang B, et al. Adventures in Scaffold Morphing: Discovery of Fused Ring Heterocyclic Checkpoint Kinase 1 (CHK1) Inhibitors. J Med Chem. 2018 Feb 8;61(3):1061-1073. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

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CHK1-IN-2

All Checkpoint Kinase (Chk) Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

CHK1-IN-2 Related Classifications

HY-111369 Related Classifications