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Cat. No.: HY-12648

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FASN-IN-4

3 Cited Publications

고객리뷰

Based on 3 publication(s) in Google Scholar

FASN-IN-4 is a potent inhibitor of fatty acid synthase (FASN) with an IC₅₀ of 10 nM (WO2012064642A1, compound 29). FASN-IN-4 also inhibits SARS-CoV-2 with an EC₅₀ of 18.6 nM.

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Purity: 99.21%
CAS No.: 1375105-96-6
화학식: C₂₆H₂₇N₃O₄S
분자량:477.58

보관:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

FASN-IN-4 Chemical Structure

CAS No.: 1375105-96-6

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (3)
순도&문서
References
Calculators
Help & FAQs
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Bioz

Biological Activity

제품 설명

FASN-IN-4 is a potent inhibitor of fatty acid synthase (FASN) with an IC₅₀ of 10 nM (WO2012064642A1, compound 29)^[1]. FASN-IN-4 also inhibits SARS-CoV-2 with an EC₅₀ of 18.6 nM^[2].

IC₅₀ & Target

IC50: 10 nM (FASN)^[1]
EC50: 18.6 nM (SARS-CoV-2)^[2]

In Vitro

The FASN inhibitor, FASN-IN-4 inhibits SARS-CoV-2 replication, and has the potential for COVID-19 research^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1375105-96-6
Appearance Solid
분자량 477.58
화학식 C₂₆H₂₇N₃O₄S
Color White to off-white
SMILES

O=C1COC2(CCN(S(=O)(C3=CC=C(C4=CC=C5C=CC=NC5=C4)C=C3)=O)CC2)CN1C6CC6
선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (3)

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Journal Impact Factor

Nat Metab

Pharmacological inhibition of fatty acid synthesis blocks SARS-CoV-2 replication. [Abstract]

2021 Nov;3(11):1466-1475. PMID: 34580494
Sci China Life Sci

NPC1-regulated dynamic of clathrin-coated pits is essential for viral entry. [Abstract]

2022 Feb;65(2):341-361. PMID: 34047913
Cell Biosci

Super-enhancer-associated INSM2 regulates lipid metabolism by modulating mTOR signaling pathway in neuroblastoma. [Abstract]

2022 Sep 16;12(1):158. PMID: 36114560

순도&문서

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Nicholas D. Adams, et al. Fatty acid synthase inhibitors. WO2012064642A1.

[2]. Junjun Chu, et al. Pharmacological inhibition of fatty acid synthesis blocks SARS-CoV-2 replication. Nat Metab. 2021 Nov;3(11):1466-1475. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

FASN-IN-4

3 Cited Publications

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Biological Activity
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- In Vitro
Chemical Information
Publications (3)
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FASN-IN-4

High-Throughput Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) FASN-IN-4

Biological Activity

Chemical Information

Publications (3)

순도&문서

References

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Help & FAQs

FASN-IN-4

High-Throughput Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) FASN-IN-4

Biological Activity

Chemical Information

Publications (3)

순도&문서

References

Calculators

Help & FAQs

FASN-IN-4 Related Classifications

HY-12648 Related Classifications