Lanatoside C
Based on 7 publication(s) in Google Scholar
Lanatoside C is a cardiac glycoside, can be used in the treatment of congestive heart failure and cardiac arrhythmia.Lanatoside C has an IC50 of 0.19 μM for dengue virus infection in HuH-7 cells. Lanatoside C can effectively inhibit all four serotypes of dengue virus, flavivirus Kunjin, alphavirus Chikungunya, Sindbis virus and the human enterovirus 71.
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- Purity: 99.88%
- CAS No.: 17575-22-3
- 화학식: C49H76O20
- 분자량:985.12
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Biological Activity
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) Lanatoside C
More- Sci Rep. 2026 Jan 28;16(1):6556. [Abstract]
- iScience. 2024 Nov 16;27(12):111404. [Abstract]
- Front Oncol. 2021 Jun 30:11:684316. [Abstract]
- Vet Microbiol. 2026 May:316:110992. [Abstract]
- Biochem Biophys Res Commun. 2020 Feb 19;522(4):862-868. [Abstract]
- Clin Exp Pharmacol Physiol. 2019 Jun;46(6):575-586. [Abstract]
- University of Saskatchewan. 2020 Jun 22.
Customer Validation & Images
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In Vivo Efficacy Study
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IHC
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In Vivo Efficacy Study
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IHC
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Histological Imaging/Staining
Biological Activity
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Cell Line
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Type | Value | Description | References |
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| Vero | CC50 |
>50 μM
Compound: Lanotoside C
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Cell viability measured by CellTiter-Glo assay in Vero cells at MOI 0.05 after 72hr
Cell viability measured by CellTiter-Glo assay in Vero cells at MOI 0.05 after 72hr
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10.1101/2020.03.20.999730 |
| Vero | IC50 |
>50 μM
Compound: Lanotoside C
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Antiviral activity against SARS-CoV-2 (viral titer) measured by plaque assay in Vero cells at MOI 0.0125 after 24 hr
Antiviral activity against SARS-CoV-2 (viral titer) measured by plaque assay in Vero cells at MOI 0.0125 after 24 hr
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10.1101/2020.03.20.999730 |
Dose-dependent reduction in dengue viral RNA and viral proteins synthesis were also observed upon treatment with increasing concentrations of Lanatoside C. Time of addition study indicated that Lanatoside C inhibits the early processes of the dengue virus replication cycle. Furthermore, Lanatoside C can effectively inhibit all four serotypes of dengue virus, flavivirus Kunjin, alphavirus Chikungunya and Sindbis virus as well as the human enterovirus 71. Lanatoside C possesses broad spectrum antiviral activity against several groups of positive-sense RNA viruses[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 17575-22-3
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Appearance Solid
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분자량 985.12
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화학식 C49H76O20
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Color White to off-white
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SMILES
O[C@]([C@@](CC[C@@]1([H])[C@@]2(CC[C@H](O[C@@](O[C@H](C)[C@H]3O[C@@](O[C@H](C)[C@H]4O[C@@](O[C@H](C)[C@H]5O[C@]([C@@H]([C@@H](O)[C@@H]6O)O)([H])O[C@@H]6CO)([H])C[C@@H]5OC(C)=O)([H])C[C@@H]4O)([H])C[C@@H]3O)C1)C)([H])[C@]2([H])C[C@H]7O)(CC[C@@H]8C(CO9)=CC9=O)[C@]78C
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Structure Classification
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Initial Source
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (7)
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Journal Impact Factor
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Most Recent
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Sci Rep
Lanatoside C ameliorates DSS-induced colitis with improved intestinal barrier integrity and reduced M1 macrophage polarization. [Abstract]2026 Jan 28;16(1):6556. PMID: 41606129
Lanatoside C purchased from MedChemExpress. Usage Cited in: Sci Rep. 2026 Jan 28;16(1):6556. [Abstract]
To evaluate the therapeutic potential of LanaC (Lanatoside C, 100 mg/kg, daily, ig) in UC, mice were administered 3% DSS in drinking water for 7 days, followed by normal water for 3 days to induce experimental colitis.
Lanatoside C purchased from MedChemExpress. Usage Cited in: Sci Rep. 2026 Jan 28;16(1):6556. [Abstract]
LanaC (Lanatoside C, 100 mg/kg, daily, ig) alleviates DSS-induced colitis symptoms. H&E staining (upper: 100 × , lower: 400 ×) reveals histological alterations in colon tissue. Scale bars represent 100 μm.
Lanatoside C purchased from MedChemExpress. Usage Cited in: Sci Rep. 2026 Jan 28;16(1):6556. [Abstract]
LanaC (Lanatoside C, 100 mg/kg, daily, ig) alleviates DSS-induced colitis symptoms. Colon length and representative images of the colon for each groups.
Lanatoside C purchased from MedChemExpress. Usage Cited in: Sci Rep. 2026 Jan 28;16(1):6556. [Abstract]
LanaC (Lanatoside C, 100 mg/kg, daily, ig) reduces DSS-induced intestinal barrier damage. Analysis of Claudin4, Occludin, and ZO1 protein expression level in colon tissue by immunohistochemistry.
Lanatoside C purchased from MedChemExpress. Usage Cited in: Sci Rep. 2026 Jan 28;16(1):6556. [Abstract]
LanaC (Lanatoside C, 100 mg/kg, daily, ig) reduces DSS-induced intestinal barrier damage. Alcian Blue–PAS staining (upper: 200 × , lower: 400 ×) and goblet cell counting in colon tissue.
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iScience
A combined AI and cell biology approach surfaces targets and mechanistically distinct Inflammasome inhibitors. [Abstract]2024 Nov 16;27(12):111404. PMID: 39687021 -
Front Oncol
2021 Jun 30:11:684316. PMID: 34277430 -
Vet Microbiol
The Chinese medicine monomer Schisandrin C inhibits PRRSV infection by regulating the OGT-PI3K/AKT/mTOR signaling pathway. [Abstract]2026 May:316:110992. PMID: 41865607 -
Biochem Biophys Res Commun
Combinatorial screening of a panel of FDA-approved drugs identifies several candidates with anti-Ebola activities. [Abstract]2020 Feb 19;522(4):862-868. PMID: 31806372 -
Clin Exp Pharmacol Physiol
Lanatoside C protects mice against bleomycin-induced pulmonary fibrosis through suppression of fibroblast proliferation and differentiation. [Abstract]2019 Jun;46(6):575-586. PMID: 30854687 -
용액&용해도
DMSO : 50 mg/mL (50.76 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Ethanol : 2 mg/mL (2.03 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (2.11 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (2.11 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Add each solvent one by one: 10% EtOH 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 0.2 mg/mL (0.20 mM); Clear solution
This protocol yields a clear solution of ≥ 0.2 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (2.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% EtOH 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 0.2 mg/mL (0.20 mM); Clear solution
This protocol yields a clear solution of ≥ 0.2 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (2.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Add each solvent one by one: 10% EtOH 90% Corn Oil
Solubility: ≥ 0.2 mg/mL (0.20 mM); Clear solution
This protocol yields a clear solution of ≥ 0.2 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (2.0 mg/mL) to 900 μL Corn oil, and mix evenly.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
순도&문서
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Data Sheet (276 KB)
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SDS (645 KB)
- English - EN (645 KB)
- Français - FR (645 KB)
- Deutsch - DE (645 KB)
- Norwegian - NO (645 KB)
- Español - ES (645 KB)
- Swedish - SV (645 KB)
- Italian - IT (645 KB)
- Korean - KR (645 KB)
- Portuguese - PT (645 KB)
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Handling Instructions (2659 KB)
References
[1]. Crommentuijn MH, et al. Intracranial AAV-sTRAIL combined with lanatoside C prolongs survival in an orthotopic xenograft mouse model of invasive glioblastoma. Mol Oncol. 2015 Dec 11. pii: S1574-7891(15)00226-4. [Content Brief]
[2]. Cheung YY, et al. Antiviral activity of lanatoside C against dengue virus infection. Antiviral Res. 2014 Nov;111:93-99. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| Ethanol / DMSO | 1 mM | 1.0151 mL | 5.0755 mL | 10.1510 mL | 25.3776 mL |
| DMSO | 5 mM | 0.2030 mL | 1.0151 mL | 2.0302 mL | 5.0755 mL |
| 10 mM | 0.1015 mL | 0.5076 mL | 1.0151 mL | 2.5378 mL | |
| 15 mM | 0.0677 mL | 0.3384 mL | 0.6767 mL | 1.6918 mL | |
| 20 mM | 0.0508 mL | 0.2538 mL | 0.5076 mL | 1.2689 mL | |
| 25 mM | 0.0406 mL | 0.2030 mL | 0.4060 mL | 1.0151 mL | |
| 30 mM | 0.0338 mL | 0.1692 mL | 0.3384 mL | 0.8459 mL | |
| 40 mM | 0.0254 mL | 0.1269 mL | 0.2538 mL | 0.6344 mL | |
| 50 mM | 0.0203 mL | 0.1015 mL | 0.2030 mL | 0.5076 mL |
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