AB21
AB21 is a potent and selective S1R antagonist with Kis of 13, 102 nM for S1R and S2R. AB21 has the effect of reducing mechanical hypersensitivity.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- CAS No.: 3026677-23-3
- 화학식: C23H28N2O
- 분자량:348.48
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Biological Activity
제품 설명
IC50 & Target
[1]|
Sigma 1 Receptor 13 nM (Ki) |
Sigma 2 Receptor 102 nM (Ki) |
In Vitro
AB21 shows Kis of 12 nM and 14 nM with or without Phenytoin in the S1R Radioligand Binding Assay[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Capsaicin-induced mechanical hypersensitivity model in mice[1]
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Dosage:20 mg/kg
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Administration:Subcutaneous injection (s.c.); administered 30 min before the injection of capsaicin
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Result:Result: Showed complete reversal of the mechanical hypersensitivity reaction and the dose administered was half that of BD-1063 (40 mg/kg).
Chemical Information
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CAS No. 3026677-23-3
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분자량 348.48
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화학식 C23H28N2O
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SMILES
O=C(N(CC1)CCC21CN(CCC3=CC=CC=C3)C2)CC4=CC=CC=C4
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AB21 Related Classifications
HY-149854 Related Classifications
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