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Cat. No.: HY-118056

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ABD459

ABD459 is a CB1 receptor antagonist with significant effects on regulating food intake and sleep-wake cycles. ABD459 completely displaces CB1 agonist CP99540 (K_i = 8.6 nM) and antagonizes CP55940-induced GTPγS binding (K_B = 7.7 nM). ABD459 may specifically modulate endogenous cannabinoid release through cholinergic activity and plays a role in attention and arousal regulation. ABD459 is suitable for research in neurological disorders.

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CAS No.: 1047670-51-8
화학식: C₂₄H₁₇BrCl₂N₂O₂
분자량:516.21

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

ABD459 Chemical Structure

CAS No.: 1047670-51-8

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

제품 설명

All Cannabinoid Receptor Isoforms :

Chemical Information

CAS No. 1047670-51-8
분자량 516.21
화학식 C₂₄H₁₇BrCl₂N₂O₂
SMILES

O=C(C1=NN(C(C2=CC=C(Br)C=C2)=C1C)C3=CC=C(C=C3Cl)Cl)C4=CC=C(C=C4)OC
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Goonawardena AV, et al. Modulation of food consumption and sleep-wake cycle in mice by the neutral CB1 antagonist ABD459. Behav Pharmacol. 2015 Apr;26(3):289-303. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
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Chemical Information
순도&문서
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ABD459

All Cannabinoid Receptor Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

ABD459 Related Classifications

HY-118056 Related Classifications