ADEP-14

ADEP-14 (preincubated for 10 min) potently activates the proteolytic activity of purified Neisseria meningitidis ClpP and Escherichia coli ClpP in casein-FITC degradation assays. It exhibits high binding affinity, and its EC₅₀ value shows a linear correlation with ClpP concentration^[1].
ADEP-14 (Compound 26) potently inhibits the growth of wild-type Neisseria meningitidis H44/76 (MIC = 0.0313 μg/mL) and Neisseria gonorrhoeae N.279 (MIC = 0.0078 μg/mL). Its activity depends on functional ClpP, and it exhibits only limited activity against membrane-compromised Escherichia coli strains (MIC = 4 μg/mL)^[2].
ADEP-14 potently inhibits the growth of all tested Gram-positive strains, including MRSA (MIC = 0.125 μg/mL) and VRE (MIC = 0.0039 μg/mL); for Streptococcus pneumoniae D39, Bacillus subtilis PY79 and Listeria innocua, its MIC values are ≤0.0625 μg/mL^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.