Amustaline
Amustaline (S-303) is a compound used for inactivating pathogens in blood components and belongs to the category of nucleic acid-targeted chemical decontaminants. Amustaline has the ability to inactivate viruses and is effective against mosquito-borne viruses such as Chikungunya virus (CHIKV), Dengue virus (DENV), and Zika virus (ZIKV). When combined with glutathione (Glutathione, GSH), which acts as a neutralizer to counteract adverse reactions, Amustaline ensures the stability of red blood cell membranes. Amustaline is mainly used for inactivating pathogens in red blood cell concentrates (RBCC) to reduce the risk of transfusion-transmitted infections (TTI).
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- CAS No.: 878189-87-8
- 화학식: C22H25Cl2N3O2
- 분자량:434.36
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 878189-87-8
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분자량 434.36
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화학식 C22H25Cl2N3O2
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SMILES
O=C(CCNC1=C2C=CC=CC2=NC3=CC=CC=C31)OCCN(CCCl)CCCl
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Synonyms
S-303
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. Aubry M, et al. Amustaline (S-303) treatment inactivates high levels of Chikungunya virus in red-blood-cell components. [Content Brief]
[2]. Aydinok Y, et al. Amustaline-glutathione pathogen-reduced red blood cell concentrates for transfusion-dependent thalassaemia. Br J Haematol. 2019 Aug;186(4):625-636. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)