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Cat. No.: HY-155543

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Anticancer agent 135

Anticancer agent 135 (compound 26h) is a potent androgen receptor (AR) antagonist. Anticancer agent 135 can effectively block AR nuclear translocation and inhibit AR/AR-V7 heterodimerization, thereby inhibiting downstream gene transcription. Anticancer agent 135 displays potent robust efficacy in prostate cancer xenograft models.

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CAS No.: 2957914-60-0
화학식: C₂₃H₂₁F₃N₄OS
분자량:458.50

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

Anticancer agent 135 Chemical Structure

CAS No.: 2957914-60-0

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

Cellular Effect

Cell Line	Type	Value	Description	References
DU-145	IC₅₀	>50 μM Compound: 26h	Cytotoxicity against androgen receptor independent human DU-145 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Cytotoxicity against androgen receptor independent human DU-145 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 37209451]
LNCaP	IC₅₀	3.5 μM Compound: 26h	Cytotoxicity against androgen receptor dependent human LNCaP cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Cytotoxicity against androgen receptor dependent human LNCaP cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 37209451]

Chemical Information

CAS No. 2957914-60-0
분자량 458.50
화학식 C₂₃H₂₁F₃N₄OS
SMILES

FC(F)(C1=C(C=CC(N2C(N(CC2=O)CCCN3C4=CC=CC=C4CCC3)=S)=C1)C#N)F
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Xiujin Chang, et al. Discovery of thiohydantoin based antagonists of androgen receptor with efficient degradation for the treatment of prostate cancer. Eur J Med Chem. 2023 Sep 5;257:115490. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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