Anticancer agent 322
Anticancer agent 322 is a spirocyclohexane-chroman-4-one derivative. Anticancer agent 322 induces apoptosis and G1 cell cycle arrest in breast cancer cells. Anticancer agent 322 can be used for the research of breast cancer.
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- 화학식: C24H26ClNO6
- 분자량:459.92
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Biological Activity
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Chemical Information
- Protocol
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
In Vitro
Anticancer agent 322 (Compound 42) potently inhibits MCF7 breast cancer cell viability with an IC50 of 3.9 μM, while being 9.99-fold and 8.95-fold less cytotoxic to noncancerous MCF10A and VA13 cells, respectively, and moderately cytotoxic to MDAMB231 breast cancer cells[1].
Anticancer agent 322 (20 μM; 24 h) induces G1-phase cell cycle arrest and slight apoptosis in MCF7 breast cancer cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MCF7 breast cancer cells
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Concentration:20 μM
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Incubation Time:24 h
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Result:Induced a G1-phase cell cycle arrest in MCF7 cells, as shown by an increased percentage of cells in G1 phase relative to untreated controls.
Observed a slight but notable level of apoptosis in cell death analysis.
Chemical Information
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분자량 459.92
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화학식 C24H26ClNO6
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SMILES
ClC(C=C1)=CC=C1NC(COC2=CC=C3C(OC4(CCC5(OCCO5)CC4)CC3O)=C2)=O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anticancer agent 322 Related Classifications
HY-183587 Related Classifications
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