Anticancer agent 57
Anticancer agent 57 (compound 14) potently inhibits MDA-MB-231, MDA-MB-468, and MCF-7 cell lines, with IC50s of 6.43 ~ 8.00 μM. Anticancer agent 57 induces cell cycle arrest and significantly promotes apoptosis. Anticancer agent 57 inhibits tumor growth in nude mice xenografted with MADMB-231 cells. Anticancer agent 57 can be used for researching triple negative breast cancer (TNBC).
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- CAS No.: 2408017-71-8
- 화학식: C20H21Cl2NO2
- 분자량:378.29
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocol
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
IC50 & Target
IC50: 8.00 ± 0.07 μM in MDA-MB-231, 7.30 ± 0.04 μM in MDA-MB-468, 6.43 ± 0.18 μM in MCF-7[1]
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MCF7 | IC50 |
2.44 μM
Compound: 14
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Antimigratory activity in human MCF7 cells assessed as inhibition of cell motility after 24 hrs by microscopic analysis
Antimigratory activity in human MCF7 cells assessed as inhibition of cell motility after 24 hrs by microscopic analysis
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[PMID: 31838326] |
| MCF7 | IC50 |
6.43 μM
Compound: 14
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Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth measured after 48 hrs by microplate reader analysis
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth measured after 48 hrs by microplate reader analysis
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[PMID: 31838326] |
| MDA-MB-231 | IC50 |
3 μM
Compound: 14
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Antimigratory activity in human MDA-MB-231 cells assessed as inhibition of cell motility after 24 hrs by microscopic analysis
Antimigratory activity in human MDA-MB-231 cells assessed as inhibition of cell motility after 24 hrs by microscopic analysis
|
[PMID: 31838326] |
| MDA-MB-231 | IC50 |
3.94 mM
Compound: Fig 1C, Cpd 2
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Antiproliferative activity against human MDA-MB-231 cells
Antiproliferative activity against human MDA-MB-231 cells
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[PMID: 38750906] |
| MDA-MB-231 | IC50 |
8 μM
Compound: 14
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Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth measured after 48 hrs by microplate reader analysis
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth measured after 48 hrs by microplate reader analysis
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[PMID: 31838326] |
| MDA-MB-468 | IC50 |
7.3 μM
Compound: 14
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Antiproliferative activity against human MDA-MB-468 cells assessed as inhibition of cell growth measured after 48 hrs by microplate reader analysis
Antiproliferative activity against human MDA-MB-468 cells assessed as inhibition of cell growth measured after 48 hrs by microplate reader analysis
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[PMID: 31838326] |
Chemical Information
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CAS No. 2408017-71-8
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분자량 378.29
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화학식 C20H21Cl2NO2
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SMILES
O=C(C1=CC=CC(OC)=C1)/C=C/C2=CC=C(N(CCCl)CCCl)C=C2
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anticancer agent 57 Related Classifications
HY-146452 Related Classifications
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