Antimicrobial agent-50
Antimicrobial agent-50 is an anti-oomycete and Fungicidal agent. Antimicrobial agent-50 inhibits the activity of Mitochondrial respiratory chain complex III with an IC50 of 6.05 mg/L. Antimicrobial agent-50 inhibits ATP synthesis. Antimicrobial agent-50 exhibits protective activity against Phytophthora capsici in vivo. Antimicrobial agent-50 potently inhibits mycelial growth of Gaeumannomyces graminis, Rhizoctonia solani and Phytophthora capsici, with EC50 values of 2.97 mg/L, 1.86 mg/L and 0.74 mg/L, respectively.
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- CAS No.: 177776-73-7
- 화학식: C17H14O3
- 분자량:266.29
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Antimicrobial agent-50 (Compound C2) (0.39-50.00 mg/L) potently inhibits mycelial growth of Gaeumannomyces graminis, Rhizoctonia solani and Phytophthora capsici, with EC50 values of 2.97 mg/L, 1.86 mg/L and 0.74 mg/L, respectively. At a concentration of 50.00 mg/L, this compound exhibits broad-spectrum in vitro fungicidal activity against another 6 tested phytopathogenic fungi/oomycetes[1].
Antimicrobial agent-50 causes severe ultrastructural damage to Phytophthora capsici hyphae, including cell wall thickening, mitochondrial degradation, and vacuole enlargement[1].
Antimicrobial agent-50 (12.50-50.00 mg/L) significantly inhibits the respiratory metabolism of Phytophthora capsici hyphae in a concentration-dependent manner, with an inhibition rate of 75.3% at 50.00 mg/L after 4 h of treatment[1].
Antimicrobial agent-50 (1-100 mg/L) inhibits the activity of mitochondrial respiratory chain complex III in Phytophthora capsici, with an IC50 of 6.05 mg/L, thereby causing a concentration-dependent decrease in intracellular ATP levels[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Adult worker honeybees[1]
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Dosage:500 mg/L; 5000 mg/L; 50000 mg/L; >200 μg/bee
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Administration:topical application to thorax; single dose
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Result:Determined LD50 greater than 200 μg/bee.
Caused less than 10% mortality at dose greater than 200 μg/bee.
Chemical Information
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CAS No. 177776-73-7
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분자량 266.29
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화학식 C17H14O3
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SMILES
O=C1OC(C2=CC=CC(OC3=CC=CC=C3)=C2)CC1=C
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
- Antimicrobial agent-50
- 177776-73-7
- Antimicrobial agent50
- Antimicrobial agent 50
- Fungal
- Mitochondrial Metabolism
- ATP Synthase
- adult worker honeybees
- Xanthomonas oryzae pv oryzae
- Pseudomonas syringae pv actinidiae
- Phytophthora capsici
- pepper seedlings
- mitochondrial respiratory chain
- Rhizoctonia solani
- ATP synthesis
- Gaeumannomyces graminis
- respiratory chain complex III
- Inhibitor
- inhibitor
- inhibit