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Cat. No.: HY-151400

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Antimicrobial agent-6

Antimicrobial agent-6 (Compound 11) is an antimicrobial agent with a MIC range of 4-8 μg/mL against gram-positive and gram-negative bacteria. Antimicrobial agent-6 also shows anti-inflammatory activity.

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CAS No.: 2978694-10-7
화학식: C₄₀H₆₄N₁₆
분자량:769.04

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

Antimicrobial agent-6 Chemical Structure

CAS No.: 2978694-10-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

In Vitro

Antimicrobial agent-6 (Compound 11) (0-256 μg/mL; 18-24 h) shows antibacterial activity with geometric mean (GM) values of the MICs of 5 μg/mL^[1].
Antimicrobial agent-6 shows minimum hemolytic concentration (MHC) of >256 μg/mL, the therapeutic index is 102.4^[1].
Antimicrobial agent-6 (5 or 20 μg/mL; 18 h) effectively inhibits the release and expression of NO and TNF-α from LPS-stimulated RAW 264.7 cells^[1].
Antimicrobial agent-6 is resistant to various physiological salts, human serum, and proteases^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

E. coli [KCTC 1682], P. aeruginosa [KCTC 1637], S. epidermidis [KCTC 1917] and S. aureus [KCTC1621]
Concentration:

0-256 μg/mL
Incubation Time:

18-24 h
Result:

Inhibited bacterial growth with MICs of 8, 4, 4 and 4 μg/mL against E. coli [KCTC 1682], P. aeruginosa [KCTC 1637], S. epidermidis [KCTC 1917] and S. aureus [KCTC1621], respectively.

RT-PCR^[1]

Cell Line:

LPS-stimulated RAW 264.7 macrophages
Concentration:

5 μg/mL (for NO/iNOS) and 20 μg/mL (for TNF-α)
Incubation Time:

18 h
Result:

Effectively inhibited the production and expression of NO and TNF-α from LPS-stimulated RAW 264.7 cells.

Chemical Information

CAS No. 2978694-10-7
분자량 769.04
화학식 C₄₀H₆₄N₁₆
SMILES

NCCCCNC1=NC(NCCCCN)=NC(N(C(CN2C3=NC(NCCCCN)=NC(NCCCCN)=N3)CC4=CC=CC=C4)CC2CC5=CC=CC=C5)=N1
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Dinesh Kumar S, et al. Cationic, amphipathic small molecules based on a triazine-piperazine-triazine scaffold as a new class of antimicrobial agents. Eur J Med Chem. 2022 Sep 8;243:114747. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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