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Cat. No.: HY-188047

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AS3580239

AS3580239 is a positive allosteric modulator of skeletal muscle-type nicotinic acetylcholine receptor (m-nAChR). AS3580239 promotes acetylcholine (ACh) signaling via m-nAChR, causing a leftward shift of the ACh concentration-response curve. AS3580239 enhances electrically stimulated isometric contraction of the extensor digitorum longus (EDL) muscle. AS3580239 improves neurotransmission and enhances muscle strength. AS3580239 can be used for research on myasthenia gravis.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

화학식: C₂₇H₂₂F₃N₅O₇S₂
분자량:649.62

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

AS3580239 Chemical Structure

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

In Vitro

AS3580239 (1-10 μM) acts as a positive allosteric modulator of skeletal muscle-type nicotinic acetylcholine receptors in differentiated Hu5/KD3 human myotubes, reducing the EC₅₀ of ACh by 14.0-fold at 10 μM without inducing currents on its own, and its effects are blocked by the acetylcholine receptor antagonist tubocurarine^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

분자량 649.62
화학식 C₂₇H₂₂F₃N₅O₇S₂
SMILES

FC(F)(F)C(N=C(NC(C(N1C)=C(O)C2=C(C=C(OCC(CO)O)C=C2)S1(=O)=O)=O)S3)=C3C(C=N4)=CN=C4C5=CC=CC=C5
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Saito A, et al. Discovery and pharmacological characterization of novel positive allosteric modulators acting on skeletal muscle-type nicotinic acetylcholine receptors. Biochemical and biophysical research communications. 2023 Aug 06;668:27-34.

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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