BAY-439
BAY-439 is a human Group V Phospholipase A2 (hPLA2-G5) inhibitor. BAY-439 can be used as a chemical probe for investigating hPLA2-G5-mediated inflammatory-related diseases, especially inflammatory pain.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- 화학식: C21H24N4O2
- 분자량:364.44
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocol
- 순도&문서
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Help & FAQs
Biological Activity
제품 설명
Chemical Information
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분자량 364.44
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화학식 C21H24N4O2
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SMILES
CCNC1=NC=CC(C#CC2=CC=C(OC3CCN(C(N)=O)CC3)C=C2)=C1
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocol
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Formalin-Induced Paw Inflammation/Nociceptive Inflammation
The formalin-induced paw inflammation/nociceptive test is a chemical persistent pain model in rodents in which subcutaneous injection of formalin into the hind paw produces spontaneous nocifensive behaviors such as flinching and licking. The response is classically biphasic, consisting of an early acute phase (Phase I) reflecting direct activation of peripheral nociceptors (particularly C-fiber afferents), followed by a later prolonged phase (Phase II) associated with central sensitization in the spinal dorsal horn driven by sustained afferent input and inflammatory signaling. This model is widely used to evaluate analgesic and anti-inflammatory interventions because it captures both peripheral nociception and central sensitization processes within a single assay system.
순도&문서
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BAY-439 Related Classifications
HY-178123 Related Classifications
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